Environmental metabolomics: Biological markers for metal toxicity

García-Sevillano, M. A.; García-Barrera, Tamara; Gómez‐Ariza, José Luis

doi:10.1002/elps.201500052

Cited by 45 publications

(27 citation statements)

References 105 publications

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“…Undoubtedly, massive methods "the omics" are among the most efficient current tools. In this sense, it has been demonstrated that alterations of the homeostatic cycles are shown at the transcriptional level (transcriptomics) [93], by overexpression or inhibition of proteins (proteomics) [94] and by modifications of the metabolic cycles (metabolomics) [1,95]. On the other hand, it has been stated that approximately 1/3 of proteins need the presence of metals as cofactors to develop their function (metalloproteins) and that metals influence on more than 50% of the proteins [96].…”

Section: Omic Methodologies To Assess Health Effects Of Pesticides Anmentioning

confidence: 99%

“…Thus, metallomics allows understanding the distribution of elements, concentration at equilibrium of free metallic ions or free elements in a cellular compartment, cell or organism [98] and refers to the identity and/or quantity of metals/metalloids and their species [99]. Likewise, it has been proposed the integration of a global (holistic) view, much more realistic of the processes that takes place in the environment [95].…”

Section: Omic Methodologies To Assess Health Effects Of Pesticides Anmentioning

confidence: 99%

“…The study of reactive oxygen species (ROS) related to oxidative damage caused by contaminants is a valuable tool in environmental studies [94]. Although most amino acids are sensitive to oxidation, the thiol group of Cys affects them especially [95] so its analysis allows determining the redox state of the thiol groups of proteins [104,105], so its analysis allows determining the redox state of the thiol groups of proteins.…”

Section: Omic Methodologies To Assess Health Effects Of Pesticides Anmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic Impairments Caused by Pesticides in Mammals and Their Interactions with Other Pollutants

Rodríguez-Moro¹,

Arias-Borrego²,

Ramírez-Acosta³

et al. 2019

Pesticides - Use and Misuse and Their Impact in the Environment

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The biological systems are exposed to a complex environment in which the contaminants can interact in a synergistic/antagonistic fashion and for this reason, the study of "chemical cocktails" is of great interest to fully understand the final biological effect. To evaluate the final biological response of a pollutant, it is essential to have an adequate analytical methodology that allows the correct monitoring of environmental systems in order to establish their quality, and, when appropriate, the application of corrective measures. Undoubtedly, massive methods "the omics" are among the most efficient current tools. To this end, transcriptomics, proteomics, metabolomics and chemical speciation can provide very useful information, mainly when they are combined. However, the combination of proteomics with metabolomics has some drawbacks as the temporal space is different (i.e. metabolomics gives information about what happens right now, but it can be related with numerous post-translational modifications happened previously). In this sense, it seems that the combination of genomics with metabolomics is easier. Thus, when metabolomics data are interpreted in combination with genomic, transcriptomic and proteomic results, in the so-called systems biology approach, a holistic knowledge of the organism/process under investigation can be achieved.

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Section: Omic Methodologies To Assess Health Effects Of Pesticides Anmentioning

confidence: 99%

Section: Omic Methodologies To Assess Health Effects Of Pesticides Anmentioning

confidence: 99%

Section: Omic Methodologies To Assess Health Effects Of Pesticides Anmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Impairments Caused by Pesticides in Mammals and Their Interactions with Other Pollutants

Rodríguez-Moro¹,

Arias-Borrego²,

Ramírez-Acosta³

et al. 2019

Pesticides - Use and Misuse and Their Impact in the Environment

Self Cite

View full text Add to dashboard Cite

show abstract

“…New approaches in functional genomics and bioinformatics can help discriminate individual chemicals, or group of chemicals among complex mixtures that may contribute to adverse biological effects (Hook et al 2014). Furthermore, environmental metabolomics is an emerging field referred to the application of metabolomics to characterize the interactions of living organisms with their environment (García-Sevillano et al 2015). In Brazil, these approaches are still rare since gene expression was assessed only in 3% of studies.…”

Section: Biomarkers Used In Brazilmentioning

confidence: 99%

The use of biomarkers to assess the health of aquatic ecosystems in Brazil: a review

et al. 2016

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Organisms in polluted environments are typically exposed to a complex mixture of chemical contaminants. The great concern about the health of aquatic ecosystems has led to the increased use of biomarkers over the past years. The aim of this work was to review the papers published from 2000 to 2015, which used biomarkers to assess the health of aquatic ecosystems in Brazil. A research resulted in 99 eligible papers. More than 80% of studies were conducted in the states of São Paulo and Rio Grande do Sul. Approximately 63% of studies used fish as bioindicator, whereas the micronucleus test and biochemical analyses were the most used biomarkers. A multibiomarker approach was used by 60.6% of studies, while 39.4% used one single biomarker. Furthermore, 68% were field studies and more than 75% of these used control animals sampled at reference sites. A relationship between the biomarker responses and pollution was reported by 87% of studies; however, 43.4% of studies analyzed only one sampling period, limiting comparisons and comprehension about possible seasonal variations. This review evidenced some weak points in studies using biomarkers in Brazil, especially related to the lack of studies in two important biomes (the Pantanal and the Amazon Rainforest) and experimental designs (small sample size, sampling in one single period, use of one single biomarker). Thus, future studies should consider mainly the use of multiple biomarkers, greater sample size, seasonal sampling and water physicochemical parameters to better diagnose the health of aquatic ecosystems.

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“…This may make metabolomics a sensitive tool for evaluating the effects of external stress than other omics techniques. Environmental metabolomics is an application of metabolomics in characterizing the interaction between organisms and the environment, which allows for us to assess the actual physiological state of an organism 16 . Although nuclear magnetic resonance (NMR) spectroscopy is the primary bioanalytical tool for detecting metabolites in environmental metabolomics, mass spectrometry (MS) is beginning to revolutionize the detection ability in this field due to its higher sensitivity 17 .…”

mentioning

confidence: 99%

Metabolomics-based study reveals the effect of lead (Pb) in the culture environment on Whitmania pigra

Luo

Meng

Chen

et al. 2020

Sci Rep

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Whitmania pigra, called Mahuang (MH) in Chinese, has been used as a traditional Chinese medicine for many years and is susceptible to Pb exposure in aquaculture environments. To understand the impact of Pb in the culture environment on MHs, we carried out a 50-day culture of MHs in environments with different levels of Pb pollution. Then, tissue samples of MHs reared in the different Pb-polluted environments were collected and analysed by UPLC-Q/TOF-MS. The results showed that the Pb residue in MHs increased with increasing Pb in the culture environment. There was no significant difference in MH Pb content (P < 0.05) between the low-Pb residue group (PbL) and the blank control group (BC), and those of the middle-Pb residue group (PbM) and the high-Pb residue group (PbH) were significantly different from that of the BC group. Metabolomics results showed significant changes in 24 metabolites in the PbL, PbM and PbH groups, some of which were dose-dependent. These metabolites were mainly lipids, nucleotides, and dipeptides, which are involved in metabolic pathways such as glycerophospholipid metabolism, sphingolipid metabolism, and nucleotide metabolism. Overall, the results proved that metabolomics can be an effective tool to understand the effects of Pb on the metabolic responses of MHs.

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Environmental metabolomics: Biological markers for metal toxicity

Cited by 45 publications

References 105 publications

Metabolic Impairments Caused by Pesticides in Mammals and Their Interactions with Other Pollutants

Metabolic Impairments Caused by Pesticides in Mammals and Their Interactions with Other Pollutants

The use of biomarkers to assess the health of aquatic ecosystems in Brazil: a review

Metabolomics-based study reveals the effect of lead (Pb) in the culture environment on Whitmania pigra

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