Environmental monitoring of mutagenic/carcinogenic hazards during road paving operations with bitumens

Monarca, Silvano; Pasquini, Rossana; Sforzolini, Giuseppina Scassellati; Savino, A; Bauleo, F. A.; Angeli, G

doi:10.1007/bf00405283

Cited by 31 publications

(12 citation statements)

References 38 publications

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“…Nitrogen-, sulfur-and/or oxygen-containing PAH or their alkyl-substituted analogues may also contribute to genotoxic effects (7,8). The urinary metabolite of pyrene, 1-hydroxypyrene (1-OHP), showed a moderate association with exposure to asphalt fumes (9)(10)(11)(12) and thus may serve as a marker of internal exposure not only to PAH but also to bitumen.…”

Section: Introductionmentioning

confidence: 99%

Assessment of DNA Damage in WBCs of Workers Occupationally Exposed to Fumes and Aerosols of Bitumen

Marczyński

Raulf‐Heimsoth²,

Preuss³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We conducted a cross-shift study with 66 bitumen-exposed mastic asphalt workers and 49 construction workers without exposure to bitumen. Exposure was assessed using personal monitoring of airborne bitumen exposure, urinary 1-hydroxypyrene (1-OHP), and the sum of 1-, 2 + 9 -,3-,4-hydroxyphenanthrene (OHPH). Genotoxic effects in WBC were determined with nonspecific DNA adduct levels of 8-oxo-7, 8-dihydro-2V-deoxyguanosine (8-oxodGuo) and the formation of DNA strand breaks and alkali-labile sites. Concentration of fumes and aerosols of bitumen correlated significantly with the concentrations of 1-OHP and OHPH after shift (r s = 0.27; P = 0.03 and r s = 0.55; P < 0.0001, respectively). Bitumen-exposed workers had more DNA strand breaks than the reference group (P < 0.0001) at both time points and a significant correlation with 1-OHP and OHPH in the postshift urines (r s = 0.32; P = 0.001 and r s = 0.27; P = 0.004, respectively). Paradoxically, we measured higher levels of DNA strand breaks, although not significant, in both study groups before shift. 8-OxodGuo adduct levels did not correlate with DNA strand breaks. Further, 8-oxodGuo levels were associated neither with personal exposure to bitumen nor with urinary metabolite concentrations. Significantly more DNA adducts were observed after shift not only in bitumen-exposed workers but also in the reference group. Only low-exposed workers had significantly elevated 8-oxodGuo adduct levels before as well as after shift (P = 0.0002 and P = 0.02, respectively). Our results show that exposure to fumes and aerosols of bitumen may contribute to an increased DNA damage assessed with strand breaks.

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Section: Introductionmentioning

confidence: 99%

Assessment of DNA Damage in WBCs of Workers Occupationally Exposed to Fumes and Aerosols of Bitumen

Marczyński

Raulf‐Heimsoth²,

Preuss³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Therefore, they can be expected to be chemically similar to bitumen (Monarca et al 1987a), but they occur simultaneously with aggregate dust, solvents, additives, diesel, and other automotive exhaust. Asphalt is a mixture of bitumen and mineral matter such as stone, sand, or filler.…”

Section: Exposure Types and Levels In Road Construction Industrymentioning

confidence: 98%

“…Twenty epidemiologic studies have dealt with the cancer risk in asphalt workers and roofers (Monarca et al 1987b). These studies nevertheless have limitations, and conclusions on the specific causes of the observed excess cancer risk remained conjectural.…”

Section: Biological Exposure Of Bitumen Fumesmentioning

confidence: 99%

Recent trends of the emission characteristics from the road construction industry

Chauhan

Sharma

Shukla

et al. 2010

Environ Sci Pollut Res

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Bitumen is a black, thermoplastic, hydrocarbon material derived from the processing of crude oil. At ambient temperature, bitumen is solid and does not present any health/environmental risks. This is one of the main reasons that bitumen is widely used for road construction all over the world. But during manufacturing/modification according to its application, storage, transportation, and use of bitumen is heated giving off various hydrocarbons emissions. In recent years, there has been increasing interest in investigating the potential of bitumen emissions to cause health effects. This is mainly because of the reason that bitumen has small amount of poly-aromatic hydrocarbons, along with some other volatiles like benzene, toluene, etc., which are known to be carcinogenic in nature. Thus, assessment of the emission characteristics and health hazards of bitumen fumes may have far reaching industrial economic and public health implications. In this review, we will discuss about the emission characteristics from bitumen, asphalts, or road construction, which is mainly contributed by bitumen fumes. Sampling strategies and analytical methods employed are also described briefly.

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“…In fact, several carcinogenic or cocarcinogenic constituents have been discovered in these products. A number of authors have shown the presence of polycyclic aromatic hydrocarbons (PAHs), some of which are known to be carcinogenic or cocarcinogenic (Bingham et al, 1979;IARC, 1983), in working operations with mineral oils, tar, pitch, and bitumens (Guerin et al, 1978;Hueper and Payne, 1960;Kipling and Waldron, 1976;Lindstedt and Sollenberg, 1982;Monarca et al, 1982Monarca et al, ,1984Monarca et al, ,1987Peake and Parker, 1980;Thayer et al, 1983;Thony et al, 1975). In particular, PAHs are concentrated in the highest boiling point distillates and in the solid residues obtained from petroleum processing.…”

Section: Introductionmentioning

confidence: 96%

Chemical composition and genotoxic activity of petroleum derivatives collected in two working environments

Pasquini

Taningher²,

Monarca³

et al. 1989

Journal of Toxicology and Environmental Health

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Pitch and bitumen, two complex petroleum derivative mixtures, were studied for both their chemical composition and their mutagenic/DNA damaging activity. While bitumen revealed no genotoxic effect and low polycyclic aromatic hydrocarbons (PAHs) concentration, petroleum pitch showed a high concentration of mutagenic/carcinogenic PAHs, and also an elevated mutagenic activity when assayed by the Ames test, in the presence of postmitochondrial rat liver fractions. The in vitro mutagenic activity was detectable as frameshift mutation by assaying the pitch both as an in toto mixture and after HPLC fractionation, the most polar fractions being the most active. In contrast, both derivatives showed no in vivo DNA damage in rat liver, using the DNA alkaline elution technique and the fluorometric assay of DNA unwinding.

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Environmental monitoring of mutagenic/carcinogenic hazards during road paving operations with bitumens

Cited by 31 publications

References 38 publications

Assessment of DNA Damage in WBCs of Workers Occupationally Exposed to Fumes and Aerosols of Bitumen

Assessment of DNA Damage in WBCs of Workers Occupationally Exposed to Fumes and Aerosols of Bitumen

Recent trends of the emission characteristics from the road construction industry

Chemical composition and genotoxic activity of petroleum derivatives collected in two working environments

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