Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (β-N-methylamino-L-alanine) in neonatal rat brain

Karlsson, Oskar; Jiang, Liying; Ersson, Lisa; Malmström, Tim; Ilag, Leopold L.; Brittebo, Eva B.

doi:10.1038/srep15570

Cited by 28 publications

(21 citation statements)

References 49 publications

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“…Previous studies in rodents revealed that BMAA is taken up in tissues characterized by a high protein synthesis, i.e. in intestinal epithelium, bone marrow, lymphatic tissues such as thymus and spleen, and liver (Karlsson et al, 2009a, Andersson et al, 2013, Karlsson et al, 2014, Karlsson et al, 2015b. In accordance with these data, about 1 and 6 % of the BMAA recovered from adult rat liver and brain were released following protein hydrolysis.…”

Section: Discussionsupporting

confidence: 84%

Transfer of developmental neurotoxin β- N -methylamino- l -alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis

et al. 2016

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Section: Discussionsupporting

confidence: 84%

Transfer of developmental neurotoxin β- N -methylamino- l -alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis

et al. 2016

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“…Amongst the more reently discussed copounds with a potential to cause DNT is paracetamol (Brandlistuen et al, 2013; Liew et al, 2014; Viberg et al, 2014), but it is not clear yet whether this effect is direct or whether it requires metabolic activation. There are also indictions that the food-borne non-proteinogenic amino acid BMAA affects neurodevelopment (Karlsson et al, 2015). The same is true for acrylamide, a chemical generated from amino acid precursors during food processing (Duarte-Salles et al, 2013; Pedersen et al, 2012).…”

Section: Challenges Encountered During the Search For Reference Commentioning

confidence: 99%

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

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Ceccatelli

Daneshian

et al. 2016

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127

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SummaryThere is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to result from the modulation of fundamental neurodevelopmental processes (such as neuronal differentiation, precursor cell migration or neuronal network formation) by chemicals, the first generation of alternative DNT tests target these processes. The advantage of such types of assays is that they capture toxicants with multiple targets and modes-of-action. Moreover, the processes modelled by the assays can be linked to toxicity endophenotypes, i.e. alterations in neural connectivity that form the basis for neurofunctional deficits in man. The authors of this review convened in a workshop to define criteria for the selection of positive/negative controls, to prepare recommendations on their use, and to initiate the setup of a directory of reference chemicals. For initial technical optimization of tests, a set of >50 endpoint-specific control compounds was identified. For further test development, an additional “test” set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. A tabular compilation of the original literature used to select the test set chemicals provides information on statistical procedures, and toxic/non-toxic doses (both for pups and dams). Suggestions are provided on how to use the >100 compounds (including negative controls) compiled here to address specificity, adversity and use of alternative test systems.

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“…Amongst the more recently discussed compounds with a potential to cause DNT is paracetamol (Brandlistuen et al, 2013;Liew et al, 2014;Viberg et al, 2014), but it is not clear yet whether this effect is direct or whether it requires metabolic activation. There are also indications that the food-borne non-proteinogenic amino acid BMAA affects neurodevelopment (Karlsson et al, 2015). The same is true for acrylamide, a chemical generated from amino acid precursors during food processing (Duarte-Salles et al, 2013;Pedersen et al, 2012).…”

Section: Examples Of Other Compounds Not Considered Herementioning

confidence: 93%

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use_suppl

Aschner

2017

ALTEX

View full text Add to dashboard Cite

SummaryThere is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to result from the modulation of fundamental neurodevelopmental processes (such as neuronal differentiation, precursor cell migration or neuronal network formation) by chemicals, the first generation of alternative DNT tests target these processes. The advantage of such types of assays is that they capture toxicants with multiple targets and modes-of-action. Moreover, the processes modelled by the assays can be linked to toxicity endophenotypes, i.e., alterations in neural connectivity that form the basis for neurofunctional deficits in man. The authors of this review convened in a workshop to define criteria for the selection of positive/negative controls, to prepare recommendations on their use, and to initiate the setup of a directory of reference chemicals. For initial technical optimization of tests, a set of > 50 endpoint-specific control compounds was identified. For further test development, an additional "test" set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. A tabular compilation of the original literature used to select the test set chemicals provides information on statistical procedures, and toxic/non-toxic doses (both for pups and dams). Suggestions are provided on how to use the > 100 compounds (including negative controls) compiled here to address specificity, adversity and use of alternative test systems.

show abstract

Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (β-N-methylamino-L-alanine) in neonatal rat brain

Cited by 28 publications

References 49 publications

Transfer of developmental neurotoxin β- N -methylamino- l -alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis

Transfer of developmental neurotoxin β- N -methylamino- l -alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use_suppl

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