Environmental occurrence, toxicity concerns, and biodegradation of neonicotinoid insecticides

Zhang, Xidong; Huang, Yaohua; Chen, Wenjuan; Wu, Siyi; Lei, Qiqi; Zhou, Zhe; Zhang, Wenping; Mishra, Sandhya; Bhatt, Pankaj; Chen, Shaohua

doi:10.1016/j.envres.2022.114953

Cited by 76 publications

(20 citation statements)

References 166 publications

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“…Bees biosynthesize limited types of enzymes endogenously that can be enhanced by phytochemicals, but a large pool of candidate bacteria could generate more types of enzymes to efficiently detoxify various pesticides that bees cannot. Bees obtain exogenous bacteria from natural food (namely, horizontal transmission) or endogenous bacteria mainly from former generations (vertical transmission), with the latter being dominant in eusocial bees (honey bees and bumble bees) in nature. ,, In addition, more exogenous bacteria may be used for probiotic formulations that are (1) found in the environment (soil, water, or sediment) and selected for bioremediation of pesticide-contaminated environments, (2) found in plants, animals, and insects that evolved to be capable of detoxifying pesticides, or (3) currently used in probiotics for humans, animals, and bees. ,− A series of bacteria have demonstrated the capacity to detoxify pyrethroids, − organophosphates, ,, neonicotinoids, − a combination of several insecticides, and herbicides and fungicides (Supporting Information Table 2). More bacterial candidates can be discovered by genomic and omic technology as well as microbe databases. ,,− …”

Section: Sources Of Potential 3p Candidatesmentioning

confidence: 99%

“…The microbial ecology of bee guts should be taken into consideration when selecting appropriate microbe species/strains or enzymes, since the detoxification capability of both microbes and enzymes are affected by factors such as pH, temperature, and oxygen. , Most microbes and enzymes prefer slightly acidic environments over slightly basic environments to achieve optimal detoxification. − In contrast, honey bees have highly acid guts which may reduce the pool of candidate bacteria and enzymes for 3P. ,, For enzymes, however, a series of techniques can stabilize the enzymatic function, allowing for more flexibility when selecting candidate enzymes. This can be achieved by various immobilization techniques that protect enzymatic structure, such as encapsulation or cross-linking by microparticles. , Food passes through bee guts in about 3 days so candidate 3P should react to pesticides rapidly to avoid pesticide absorption and consequential toxicity.…”

Section: Impact Of Gut Hive and Landscape Environment And Bee Sociali...mentioning

confidence: 99%

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Phytochemicals, Probiotics, Recombinant Proteins: Enzymatic Remedies to Pesticide Poisonings in Bees

Zhang,

Dilday,

Kuesel

et al. 2023

Environ. Sci. Technol.

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The ongoing global decline of bees threatens biodiversity and food safety as both wild plants and crops rely on bee pollination to produce viable progeny or high-quality products in high yields. Pesticide exposure is a major driving force for the decline, yet pesticide use remains unreconciled with bee conservation since studies demonstrate that bees continue to be heavily exposed to and threatened by pesticides in crops and natural habitats. Pharmaceutical methods, including the administration of phytochemicals, probiotics (beneficial bacteria), and recombinant proteins (enzymes) with detoxification functions, show promise as potential solutions to mitigate pesticide poisonings. We discuss how these new methods can be appropriately developed and applied in agriculture from bee biology and ecotoxicology perspectives. As countless phytochemicals, probiotics, and recombinant proteins exist, this Perspective will provide suggestive guidance to accelerate the development of new techniques by directing research and resources toward promising candidates. Furthermore, we discuss practical limitations of the new methods mentioned above in realistic field applications and propose recommendations to overcome these limitations. This Perspective builds a framework to allow researchers to use new detoxification techniques more efficiently in order to mitigate the harmful impacts of pesticides on bees.

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Section: Sources Of Potential 3p Candidatesmentioning

confidence: 99%

Section: Impact Of Gut Hive and Landscape Environment And Bee Sociali...mentioning

confidence: 99%

Phytochemicals, Probiotics, Recombinant Proteins: Enzymatic Remedies to Pesticide Poisonings in Bees

Zhang,

Dilday,

Kuesel

et al. 2023

Environ. Sci. Technol.

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“…As the name implies, insecticides are chemicals used to kill insects to protect cultivated plants or to mitigate disease-carrying insects in some regions. Insecticides harm insects by disrupting their nervous system [44]. Neonicotinoids such as acetamiprid, thiacloprid and imidacloprid are a class of synthetic neuro-active insecticides widely used for insect control.…”

Section: Pesticides Classification and Characteristicsmentioning

confidence: 99%

Microalgae-Enabled Wastewater Treatment: A Sustainable Strategy for Bioremediation of Pesticides

Sean

Lau

Ismail

et al. 2022

Water

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Pesticides have been identified as major contaminants of various waterways. Being classified as potential endocrine disrupting compounds, pesticides in aqueous system are highly hazardous to aquatic organisms and the ecosystem. The treatment of pesticide-containing wastewater can be performed through several means, but a wastewater treatment strategy which emphasizes both treatment efficiency and sustainability is a necessity of current time. In this context, bioremediation has been increasingly promoted as an alternative technique for the remediation of diverse pollutants. Particularly, bioremediation which involves the utilization of microalgae for the removal or conversion of pesticides to the harmless or less harmful compounds is becoming a trend. Exploiting microalgae as a tool for wastewater treatment presents multiple advantages over conventional treatment technologies, which include an opportunity to simultaneously treat pesticide-containing wastewater and nutrient recovery for microalgae cultivation as well as less formation of toxic sludge. This review discusses the roles of microalgae in mitigating pesticide pollution issue, while offering an opportunity for nutrient recovery from various wastewater sources. Based on the current laboratory studies, the use of microalgae bioremediation as a promising strategy for pesticide treatment has been rationalized. The establishment of more pilot scale studies is highly encouraged to further facilitate the implementation of this treatment approach for practical application.

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“…Although it has recently been reported that neonicotinoids have very low toxic effects on mammals, studies have revealed that they can cause, at chronic exposures, serious toxic effects. These chemicals could accumulate in the environment [ 1 , 2 ]. Their toxic effects, particularly on honey bees and mammals, resulted in their gradual withdrawal from the market.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Sevim

Akpınar

Aksu

et al. 2023

Toxics

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The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.

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Environmental occurrence, toxicity concerns, and biodegradation of neonicotinoid insecticides

Cited by 76 publications

References 166 publications

Phytochemicals, Probiotics, Recombinant Proteins: Enzymatic Remedies to Pesticide Poisonings in Bees

Phytochemicals, Probiotics, Recombinant Proteins: Enzymatic Remedies to Pesticide Poisonings in Bees

Microalgae-Enabled Wastewater Treatment: A Sustainable Strategy for Bioremediation of Pesticides

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

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