In recent years, rapeseed oil has received considerable attention in the agricultural sector, experiencing appreciable growth. However, weed-related challenges are hindering the expansion of rapeseed production. This paper outlines the development of an intelligent weed detection and laser weeding system—a non-chemical and precision agricultural protection method of weeding Veronica didyma in winter rapeseed fields in the Yangtze River Basin. A total of 234 Veronica didyma images were obtained to compile a database for a deep-learning model, and YOLOv7 was used as the detection model for training. The effectiveness of the model was demonstrated, with a final accuracy of 94.94%, a recall of 95.65%, and a mAP@0.5 of 0.972 obtained. Subsequently, parallel-axis binocular cameras were selected as the image acquisition platform, with binocular calibration and semi-global block matching used to locate Veronica didyma within a cultivation box, yielding a minimum confidence and camera height values of 70% and 30 cm, respectively. The intelligent weed detection and laser weeding system was then built, and the experimental results indicated that laser weeding was practicable with a 100 W power and an 80 mm/s scanning speed, resulting in visibly lost activity in Veronica didyma and no resprouting within 15 days of weeding. The successful execution of Veronica didyma detection and laser weeding provides a new reference for the precision agricultural protection of rapeseed in winter and holds promise for its practical application in agricultural settings.