Environmental pollutants and the risk of neurological disorders

Aleya, Lotfi

doi:10.1007/s11356-020-11272-3

Cited by 16 publications

(9 citation statements)

References 7 publications

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“…Approximately 16% of the US population (about 20 million people) have brain impairment, with Alzheimer’s and epilepsy the most common in adults, excluding stroke (Pal 2018 ), followed by Parkinson’s disease and brain tumors (Pal 2018 ). Approximately 100 million people worldwide have neurological disorders, accounting for 20% of the total global disease burden (Aleya and Uddin 2020 ). The most common neurological disorders worldwide are Alzheimer’s, dementia, Parkinson’s, seizures (related to epilepsy), and brain tumors (Aleya and Uddin 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 100 million people worldwide have neurological disorders, accounting for 20% of the total global disease burden (Aleya and Uddin 2020 ). The most common neurological disorders worldwide are Alzheimer’s, dementia, Parkinson’s, seizures (related to epilepsy), and brain tumors (Aleya and Uddin 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies reported that exposure to harmful substances due to environmental pollution was associated with the occurrence of cranial nerve diseases. Exposure to air pollution, which causes chronic oxidative stress in the brain and nervous system, was reported as an important cause of Alzheimer’s disease (Aleya and Uddin 2020 ). Exposure to heavy metals and pesticides from soil contamination can lead to degenerative brain disease and cancer by increasing cranial nervous system protein folding and aggregation (Aleya and Uddin 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

Jeong

Jang

Lee

2022

J. Pharm. Investig.

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Background Cranial nerve-related diseases such as brain tumors, Alzheimer’s disease, and epilepsy are serious diseases that continue to threaten human. Brain-related diseases are increasing worldwide, including in the United States and Korea, and these increases are closely related to the exposure to harmful substances and excessive stress caused by rapid industrialization and environmental pollution. Drug delivery to the brain is very important for the effective prevention and treatment of brain-related diseases. However, due to the presence of the blood–brain barrier and the extensive first-pass metabolism effect, the general routes of administration such as oral and intravenous routes have limitations in drug delivery to the brain. Therefore, as an alternative, the nasal-brain drug delivery route is attracting attention as a route for effective drug delivery to the brain. Areas covered This review includes physiological factors, advantages, limitations, current application status, especially in clinical applications, and the necessary factors for consideration in formulation development related to nasal-brain drug delivery. Expert opinion The nasal-brain drug delivery route has the advantage of enhancing drug delivery to the brain locally, mainly through the olfactory route rather than the systemic circulation. The nasal-brain lymphatic system has recently attracted attention, and it has been implied that the delivery of anticancer drugs to the brain nervous system is possible effectively. However, there are limitations such as low drug permeability, as well as nasal mucosa and the mucociliary system, as obstacles in nasal-brain drug delivery. Therefore, to overcome the limitations of nasal-brain drug delivery, the use of nanocarriers and mucoadhesive agents is being attempted. However, very few drugs have been officially approved for clinical application via the nasal-brain drug delivery route. This is probably because the understanding of and related studies on nasal-brain drug delivery are limited. In this review, we tried to explore the major considerations and target factors in drug delivery through the nasal-brain route based on physiological knowledge and formulation research information. This will help to provide a mechanistic understanding of drug delivery through the nasal-brain route and bring us one step closer to developing effective formulations and drugs in consideration of the key factors for nasal-brain drug delivery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

Jeong

Jang

Lee

2022

J. Pharm. Investig.

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“…The pollutants in the environment will accumulate in the body through the food chain 38–40 . Exposure to the pollutants may induce a variety of diseases 41–43 .…”

Section: Discussionmentioning

confidence: 99%

Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis

Han

et al. 2021

Environmental Toxicology

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Mercury as a toxic heavy metal will accumulate in the body and induce various diseases through the food chain. However, it is unknown that the detailed mechanism of reproductive disorder induced by inorganic mercury in male mice to date. This study investigated the toxicological effect of mercuric chloride (HgCl2) exposure on reproductive system in male mice. Male Kunming mice received normal saline daily or HgCl2 (3 mg/kg bodyweight) by intraperitoneal injection for a week. The reproductive function was evaluated, and the HgCl2 exposure induced the decline of sperm quality, pregnancy rate, mean litter size, and survival rate. Notably, we firstly found the HgCl2‐induced immunosuppression and fibrosis in mice testis according to the results of RNA sequencing. Collectively, these findings demonstrate that HgCl2 exposure disrupts the reproductive system and induces testicular immunosuppression and fibrosis via inhibition of the CD74 signaling pathway in male mice.

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“…Due to the increasing environmental pollution, which is majorly caused by anthropogenic activities (man-made processes), the people are now more concerned around the globe. The increasing number of various types of organic pollutants, including phenols, pharmaceuticals, pesticides, dyes, estrogens, and personal care products, is increasingly being detected in our water systems and wastewater [1][2][3]. Their presence in unknown and uncontrolled dosages undesirably compromises the quality of water and shows a serious risk to human beings and aquatic organisms [4,5].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Wastewater Treatment by Immobilized Enzymes

et al. 2021

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Purpose of Review In the presented review, we have summarized recent achievements on the use of immobilized oxidoreductases for biodegradation of hazardous organic pollutants including mainly dyes, pharmaceuticals, phenols, and bisphenols. In order to facilitate process optimization and achievement of high removal rates, effect of various process conditions on biodegradation has been highlighted and discussed. Recent Findings Current reports clearly show that immobilized oxidoreductases are capable of efficient conversion of organic pollutants, usually reaching over 90% of removal rate. Further, immobilized enzymes showed great recyclability potential, allowing their reuse in numerous of catalytic cycles. Summary Collected data clearly indicates immobilized oxidoreductases as an efficient biocatalytic tools for removal of hazardous phenolic compounds, making them a promising option for future water purification. Data shows, however, that both immobilization and biodegradation conditions affect conversion efficiency; therefore, process optimization is required to achieve high removal rates. Nevertheless, we have demonstrated future trends and highlighted several issues that have to be solved in the near-future research, to facilitate large-scale application of the immobilized oxidoreductases in wastewater treatment.

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Environmental pollutants and the risk of neurological disorders

Cited by 16 publications

References 7 publications

Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis

Enhanced Wastewater Treatment by Immobilized Enzymes

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