Environmental Radioactivity and High Incidence Rates of Stomach and Esophagus Cancer in the Van Lake Region: A Causal Relationship?

Akan, Zafer; Baskurt, Busranur; Aslıyüksek, Hızır; Kam, Erol; Yılmaz, Ahmet; Yüksel, Mehmet Bilgehan; Bıyık, Recep; Esen, Ramazan; Koca, Doğan

doi:10.7314/apjcp.2014.15.1.375

Cited by 11 publications

(5 citation statements)

References 18 publications

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“…In the indoor environment, the levels of radioactive aerosol may build up and have potential adverse health effects: higher exposure to indoor radon ( 222 Rn) has been associated with elevated lung cancer risk (Field et al 2006; IARC 1988). In the outdoor environment, the decay products of radon and thoron ( 220 Rn) contribute to the majority of radioactive exposure (Akan et al 2014) but at lower levels.…”

Section: Introductionmentioning

confidence: 99%

Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study

Nyhan

Wilker

et al. 2018

Environment International

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Background: Decay products of radioactive materials may attach to ambient fine particles and form radioactive aerosol. Internal ionizing radiation source from inhaled radioactive aerosol may contribute to the fine particulate matter (PM2.5)-inflammation pathway. However, few studies in humans have examined the associations. Objectives: To examine the associations between particle radioactivity and biomarkers of oxidative stress and inflammation among participants from the Framingham Offspring and Third Generation cohorts. Methods: We included 3,996 participants who were not current smokers and lived within 50 km from our central air pollution monitoring station. We estimated regional mean gross beta radioactivity from monitors in the northeastern U.S. as a surrogate for ambient radioactive particles, and calculated the 1- to 28-day moving averages. We used linear regression models for fibrinogen, tumor necrosis factor α, interleukin-6, and myeloperoxidase which were measured once, and linear mixed effect models for 8-epi-prostaglandin F2α, C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), P-selectin, and tumor necrosis factor receptor-2 that were measured up to twice, adjusting for demographics, individual- and area-level socioeconomic positions, time, meteorology, and PM2.5. We also examined whether the associations differed by median age, sex, diabetes status, PM2.5 levels, and black carbon levels. Results: The mean age was 54 years and 54% were women. An interquartile range (3×10−3 pCi/m3) higher beta radioactivity level at the 7-day moving average was associated with 5.09% (95% CI: 0.92, 9.43), 2.65% (1.10, 4.22), and 4.71% (95% CI: 3.01, 6.44) higher levels of interleukin-6, MCP-1, and P-selectin, but with 7.01% (95% CI: −11.64, −2.15) and 2.70% (95% CI: −3.97, −1.42) lower levels of 8-epi-prostaglandin F2α and ICAM-1, respectively. Conclusions: Regional mean particle radioactivity was positively associated with interleukin-6, MCP-1, and P-selectin, but negatively with ICAM-1 and 8-epi-prostaglandin F2α among our study participants.

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Section: Introductionmentioning

confidence: 99%

Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study

Nyhan

Wilker

et al. 2018

Environment International

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“…In this study according table 3, the mean incidence rate in distance 70 km from Sabalan with 70 per 100000 DOI:http://dx.doi.org/10.7314/APJCP.2015.16.16.6889 Relationships between Altitude and Distance from a Volcano with Stomach Cancer Incidence Using a GIS accepted (Akan et al, 2014).…”

Section: Discussionmentioning

confidence: 71%

Analysis of Relationships between Altitude and Distance from Volcano with Stomach Cancer Incidence Using a Geographic Information System

Amani

Ahari²,

Barzegari³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Gastric cancer (GC) is the fifth most common cancer in the world, with a wide variation in incidence rates across different geographical areas. In Iran GC is the most common cancer in males and it is reported to be the third most prevalent after breast and colorectal in females. A geographical information system (GIS) allows investigation of the geographical distribution of diseases. The purpose of the present study was to explore the relationship between gastric cancer and effective climatic factors using GIS. The dispersion distribution and the relationship between environmental factors effective on cancer were measured using Arc GIS. Of all cases, 672 (73.8%) were in males with a sex ratio of 3 to1. The highest incidence by cities was seen in Namin with 137.5 per 100,000. The results of this study showed that the distribution of GC around the Sabalan volcanic mountain was significantly higher than other places in the same province. These results can be considered as a window to future comprehensive research on gastric cancer.

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“…In our study, the colorectal cancer frequency was also comparable to the literature. High fat and meat consumption in the region, as well as environmental conditions, could be contributing factors [17,18].…”

Section: Discussionmentioning

confidence: 99%

Analysis of cancer cases from Dicle University Hospital; ten years’ experience

Arslan¹

2018

Ann Clin Anal Med

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Aim: Cancer is the most common mortality and morbidity reason in the world. In Turkey cancer prevalence is high, and the treatment is expensive. The most important step in preventing and treating cancer is an early diagnosis. We aimed to contribute to the literature by specifying the common cancer types and etiological factors present in Diyarbakır region. Material and Method: Archived biopsy reports of patients diagnosed with malignant cancers after histopathological evaluation were studied retrospectively. The cases were dated between 2001 and 2010 and were all taken from the Dicle University Medical Faculty Hospital. Results: In total, 3624 cases were examined according to age, gender, year, location, and pathological diagnosis. Of the patients, 41.7% of the cases were female, and 58.3% were male. The average age of the patients was 54.8 years, and the most frequent

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Environmental Radioactivity and High Incidence Rates of Stomach and Esophagus Cancer in the Van Lake Region: A Causal Relationship?

Cited by 11 publications

References 18 publications

Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study

Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study

Analysis of Relationships between Altitude and Distance from Volcano with Stomach Cancer Incidence Using a Geographic Information System

Analysis of cancer cases from Dicle University Hospital; ten years’ experience

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