Multiple land use brings with it several safety risks when buildings are developed above or nearby transport routes of hazardous materials. To reduce these risks several measures can be implemented in multiple land-use projects for both the construction and the exploitation stage. These measures will reduce either the probability and/or the consequences of an incident, but also influence the potential to develop those projects in their design and layout. This paper gives an analysis of physical and spatial safety for both the construction and exploitation stages in multiple land-use projects, and gives an overview of the spatial implications for these projects.