Environmental risk factors and gender in nasal polyposis

Abstract

The aetiology of nasal polyps remains obscure. Although clinically associated with asthma, notably in women, there is a marked male preponderance of polyposis. This study aimed to explore environmental pollutant triggers and gender differences in risk factors for nasal polyps. In total, 900 patients having surgery for polyposis and 120 new patients with nasal polyps completed a questionnaire with regard to occupational dust and chemical exposure. The male to female ratio was 2:1, and 52% were smokers, although only 37% of women smoked compared with 66% of men. Exposure to occupational dusts and chemicals was noted in 45% (retrospective) and 53% (prospective) of respondents. Women were 1.6 times more likely to be asthmatic and 2.7 times more likely to have allergic rhinitis than men. Men were 2.25 times more likely to be smokers and 2.48 times more likely to have been exposed to chemicals and dusts than women (all statistically significant differences). No significant gender associations were found for hayfever, eczema, aspirin intolerance, alcohol intake or hobby dust exposure.

Sinonasal inflammation in COPD: a systematic review

“…This too is troublesome because nasal disease with and without nasal polyps may be differently associated with smoking. COLLINS et al [19], HOUSER et al [20] and others have found smoking to be associated with nasal polyposis, a disease that is generally considered to be eosinophilic in nature, at least in Caucasians [59]. However, other studies have shown that sinonasal inflammation in COPD is skewed towards a neutrophilic response resembling CRS without nasal polyps [50][51][52]60].…”

“…COLLINS et al [19] and HOUSER et al [20] independently investigated the association between nasal polyps and smoking in two studies comprising 1020 and 373 patients, respectively. Both studies included patients undergoing surgery for nasal polyposis and they found the prevalence of smoking among nasal polyp patients to be 50-100% higher than in the background population.…”

“…In a casecontrol study, REH et al [21] found a significant association between CRS and SHS exposure either in childhood or at the time of the study. Furthermore, CRS cases that had been exposed to SHS reported more [18] 1992 Cross-sectional study 324 Yes No P COLLINS et al [19] 2002 [44] 2008 Cross sectional study and follow up study 4280 No No No HURST et al [45] 2006 Descriptive study 51 No No S KELEMENCE et al [5] 2011 Descriptive study 90 No No S VAN MANEN et al [46] 2001 Descriptive study 290 No No S ROBERTS et al [4] 2003 Descriptive study 61 No No S CORSICO et al [47] 2007 Descriptive study 212 No Yes…”

Digital Signal Processing Techniques to Improve Time Resolution in Positron Emission Tomography

“…De los casos en los que los pacientes sufren ambas enfermedades un 69% de ellos padecen el asma en primer lugar, un 21% desarrollan primero RSC-PN y el 10% restante los hace de forma prácticamente simultánea [23]. Además se ha determinado que los casos de pacientes femeninos que padecen ambas enfermedades duplican el de masculinos, al contrario de lo que ocurría en casos de RSC-PN generales, teniendo las pacientes femeninas que padecen PN una probabilidad 1,6 veces mayor de ser asmáticas y 2,7 veces mayor de ser alérgicas [24].…”

Chronic rhinosinusitis with nasal polyps. The recent trend in the studies of the pathogenesis, diagnosis and treatment of this disease

“…Соответственно уровень заболеваемости ПРС значительно выше, чем в приведенных официальных ис-точниках. Средний возраст пациентов для дебюта ПРС со-ставляет 42 года [6], мужчины подвержены этому заболева-нию чаще женщин в соотношении 2-3:1 [7].…”