This paper proposes a method of three-dimensional (3D) dynamic visualization simulation of pool fire triggered by major hazard installation. The method describes the 3D dynamic characteristics of pool fire by establishing the 3D model which combines with the real-time data of various parameters including environment and position information of people. To improve the computational efficiency of the model and enhance the sensing cognition of accidents, a 3D simulation system of pool fire is developed by 3D visualization technology. And an application of the system is performed to simulate the real-time process and consequences of pool fire. The application results show that the 3D simulation method of pool fire is of real-time, lifelike and visual characteristics, which not only embodies the great practical application value of 3D visualization technology in the field of safety engineering, but also provides references for safety management, disaster prediction, risk assessment, emergency response and safety planning of petrochemical enterprises.