Environmental Risks of Inorganic Metals and Metalloids: A Continuing, Evolving Scientific Odyssey

Chapman, Peter M.

doi:10.1080/10807030701790272

Cited by 49 publications

(24 citation statements)

References 238 publications

(173 reference statements)

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“…Despite a general consensus on the integration of different measures, biomarkers and biomonitoring criteria are a matter of study [10], [11] and the current ‘omics’ sciences greatly enlarge the repertoire of the potential indicators to be considered for validation and standardization [12], [13].…”

Section: Introductionmentioning

confidence: 99%

DNA Damage and Transcriptional Changes in the Gills of Mytilus galloprovincialis Exposed to Nanomolar Doses of Combined Metal Salts (Cd, Cu, Hg)

et al. 2013

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Aiming at an integrated and mechanistic view of the early biological effects of selected metals in the marine sentinel organism Mytilus galloprovincialis, we exposed mussels for 48 hours to 50, 100 and 200 nM solutions of equimolar Cd, Cu and Hg salts and measured cytological and molecular biomarkers in parallel. Focusing on the mussel gills, first target of toxic water contaminants and actively proliferating tissue, we detected significant dose-related increases of cells with micronuclei and other nuclear abnormalities in the treated mussels, with differences in the bioconcentration of the three metals determined in the mussel flesh by atomic absorption spectrometry. Gene expression profiles, determined in the same individual gills in parallel, revealed some transcriptional changes at the 50 nM dose, and substantial increases of differentially expressed genes at the 100 and 200 nM doses, with roughly similar amounts of up- and down-regulated genes. The functional annotation of gill transcripts with consistent expression trends and significantly altered at least in one dose point disclosed the complexity of the induced cell response. The most evident transcriptional changes concerned protein synthesis and turnover, ion homeostasis, cell cycle regulation and apoptosis, and intracellular trafficking (transcript sequences denoting heat shock proteins, metal binding thioneins, sequestosome 1 and proteasome subunits, and GADD45 exemplify up-regulated genes while transcript sequences denoting actin, tubulins and the apoptosis inhibitor 1 exemplify down-regulated genes). Overall, nanomolar doses of co-occurring free metal ions have induced significant structural and functional changes in the mussel gills: the intensity of response to the stimulus measured in laboratory supports the additional validation of molecular markers of metal exposure to be used in Mussel Watch programs.

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Section: Introductionmentioning

confidence: 99%

DNA Damage and Transcriptional Changes in the Gills of Mytilus galloprovincialis Exposed to Nanomolar Doses of Combined Metal Salts (Cd, Cu, Hg)

et al. 2013

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“…The specific mode of toxic action that a metal induces in an organism, and the organism's behaviour and metabolism (e.g. feeding behaviour, filtration rates and detoxification processes) will determine the subsequent toxic effects (Chapman 2008). Water quality parameters in tropical marine systems differ significantly from temperate systems due to natural variations in climate and geochemical factors such as temperature and increased seasonal rainfall, nutrient and DOC quality and concentration.…”

Section: Influence Of Water Quality Parameters On Nickel Toxicitymentioning

confidence: 99%

A review of nickel toxicity to marine and estuarine tropical biota with particular reference to the South East Asian and Melanesian region

Gissi

Stauber

Binet

et al. 2016

Environmental Pollution

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. (2016). A review of nickel toxicity to marine and estuarine tropical biota with particular reference to the South East Asian and Melanesian region. Environmental Pollution, 218 1308Pollution, 218 -1323 A review of nickel toxicity to marine and estuarine tropical biota with particular reference to the South East Asian and Melanesian region AbstractThe South East Asian Melanesian (SEAM) region contains the world's largest deposits of nickel lateritic ores. Environmental impacts may occur if mining operations are not adequately managed. Effects data for tropical ecosystems are required to assess risks of contaminant exposure and to derive water quality guidelines (WQG) to manage these risks. Currently, risk assessment tools and WQGs for the tropics are limited due to the sparse research on how contaminants impact tropical biota. As part of a larger project to develop appropriate risk assessment tools to ensure sustainable nickel production in SEAM, nickel effects data were required. The aim of this review was to compile data on the effects of nickel on tropical marine, estuarine, pelagic and benthic species, with a particular focus on SEAM. There were limited high quality chronic nickel toxicity data for tropical marine species, and even fewer for those relevant to SEAM. Of the data available, the most sensitive SEAM species to nickel were a sea urchin, copepod and anemone. There is a significant lack of high quality chronic data for several ecologically important taxonomic groups including cnidarians, molluscs, crustaceans, echinoderms, macroalgae and fish. No high quality chronic nickel toxicity data were available for estuarine waters or marine and estuarine sediments. The very sparse toxicity data for tropical species limits our ability to conduct robust ecological risk assessment and may require additional data generation or readacross from similar species in other databases (e.g. temperate) to fill data gaps. Recommendations on testing priorities to fill these data gaps are presented. Capsule abstractNickel toxicity data is lacking for tropical marine biota; data is required for key taxa including cnidarians, molluscs, crustaceans, echinoderms, macroalgae and fish. HighlightsSouth East Asia and Melanesia contains the largest deposits of nickel lateritic ores Environmental impacts may occur if mining operations are not adequately managed Risk assessment tools for nickel in the tropics are limited due to lack of data We compiled nickel data for aquatic tropical ecosystems and identified key gaps Nickel data is required for corals, molluscs, crustaceans, echinoderms, macroalgae, fish KeywordsMining, tropical ecotoxicology, ecological risk assessment, bioassay, species sensitivity distribution. 2 AbstractThe South East Asian Melanesian (SEAM) region contains the world's largest deposits of nickel lateritic ores. Environmental impacts may occur if mining operations are not adequately managed. Effects data for tropical ecosystems are required to assess risks of contaminant exposure and to derive water quality ...

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“…Common sediment contaminants that may biomagnify include: organic mercury; PCBs; DDT; and, 2,3,7,8-TCDD. Inorganic substances such as metals do not biomagnify (Chapman, 2008).…”

Section: Discussionmentioning

confidence: 99%

Sediment remediation can include no action

Chapman¹

2018

Ecotoxicol. Environ. Contam.

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This short Commentary briefly reviews contaminated sediment risks, the 4 factors that determine appropriate remedial alternatives, and situations where the no action (other than monitoring) alternative may be appropriate. References and an example involving mercury-contaminated sediments is provided. Remediation alternatives other than no action should not cause more environmental harm than they prevent.

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Environmental Risks of Inorganic Metals and Metalloids: A Continuing, Evolving Scientific Odyssey

Cited by 49 publications

References 238 publications

DNA Damage and Transcriptional Changes in the Gills of Mytilus galloprovincialis Exposed to Nanomolar Doses of Combined Metal Salts (Cd, Cu, Hg)

DNA Damage and Transcriptional Changes in the Gills of Mytilus galloprovincialis Exposed to Nanomolar Doses of Combined Metal Salts (Cd, Cu, Hg)

A review of nickel toxicity to marine and estuarine tropical biota with particular reference to the South East Asian and Melanesian region

Sediment remediation can include no action

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