Environmental Screening of &lt;em&gt;Aeromonas hydrophila&lt;/em&gt;, &lt;em&gt;Mycobacterium&lt;/em&gt; spp., and &lt;em&gt;Pseudocapillaria tomentosa&lt;/em&gt; in Zebrafish Systems

Mocho, Jean-Philippe; Martin, Darren J.; Millington, Mollie E.; Torres, Yolanda Saavedra

doi:10.3791/55306-v

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…24 Multiple reports of M. haemophilum have also been documented in zebrafish from a variety of regions, with disease ranging from mild pyoderma to disseminated organ dysfunction and failure. [25][26][27][28][29][30][31][32][33][34][35] Human literature suggests that multimodal antibiotic treatment based on susceptibility is the most successful treatment plan, though no standardised protocol has been published. 4 Treatment has been reported with long-term multimodal antibiotic therapy, surgical resection of granulomas when able or a combination of both.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, an Assam trinket snake ( Elphae frenata ) was found to have disseminated granulomatosis with intracellular acid‐fast bacilli, which were positive for M. haemophilum 24 . Multiple reports of M. haemophilum have also been documented in zebrafish from a variety of regions, with disease ranging from mild pyoderma to disseminated organ dysfunction and failure 25–35 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and treatment of a novel Mycobacterium haemophilum associated pneumonia in an African pygmy hedgehog (Atelerix albiventris)

Vecere

Malka

Garner³

et al. 2023

Vet Record Case Reports

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An unknown age (at least 1.5‐year old), male, entire African pygmy hedgehog (Atelerix albiventris) was presented for decreased appetite, lethargy and laboured breathing. Pulmonary radiographic lesions consistent with pneumonia were noted in serial computed tomography scans. The hedgehog initially responded well to treatment with azithromycin and orbifloxacin for several months, but its health declined upon discontinuation of treatment. After continued decline despite resumed antibiotic therapy, the patient was humanely euthanised. A postmortem examination was performed, and histologic examination identified severe granulomatous bronchointerstitial pneumonia with intralesional acid‐fast staining bacteria. Samples from the lung and liver were positive for Mycobacterium haemophilum by PCR and further DNA sequencing. This report describes the clinical presentation, diagnosis, treatment and outcome of a pulmonary infection caused by M. haemophilum in a hedgehog.

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