Environmental selection of antibiotic resistance genes

Alonso, Ana; Sánchez, Patricia; Martínez, José Luis

doi:10.1046/j.1462-2920.2001.00161.x

Cited by 350 publications

(231 citation statements)

References 81 publications

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“…However, selection can occur in the environment without antibiotic selective pressure (Alonso et al, 2001). This means that antibiotic resistance genes might be transferred and preserved in the environment with or without antibiotic selective pressure.…”

Section: Transport Of Antibiotics Resistant Bacteria Into Soil and Watermentioning

confidence: 99%

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Occurrence of Tylosin-Resistant Enterococci in Swine Manure and Tile Drainage Systems under No-Till Management

Hoang

Soupir

Liu

et al. 2013

Water Air Soil Pollut

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Section: Transport Of Antibiotics Resistant Bacteria Into Soil and Watermentioning

confidence: 99%

“…Selection of antibiotic resistance is not always a consequence of antibiotic selective pressure, selection without antibiotic pressure might also occur (Alonso et al, 2001). …”

Section: Occurrence Of Tylosin-resistant Enterococci In Manure Soilmentioning

confidence: 99%

Occurrence of Tylosin-Resistant Enterococci in Swine Manure and Tile Drainage Systems under No-Till Management

Hoang

Soupir

Liu

et al. 2013

Water Air Soil Pollut

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“…To build the most accurate predictive model possible, the relative importance of each of these causal factors should be estimated. Theoretically, the selection and persistence of an antibioticresistance gene that has been introduced into the environment might have more to do with the presence of additional genes that confer resistance to chemicals and metals or that provide an ecological fitness advantage to the cell, or with alternative sources of the antibiotic than to the presence of a primary antibiotic-selection pressure 46 .…”

Section: Selection Pressures -A Complex Arraymentioning

confidence: 99%

Erratum: Can landscape ecology untangle the complexity of antibiotic resistance?

Singer¹,

Ward²,

Maldonado³

2007

Nat Rev Microbiol

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| Bacterial resistance to antibiotics continues to pose a serious threat to human and animal health. Given the considerable spatial and temporal heterogeneity in the distribution of resistance and the factors that affect its evolution, dissemination and persistence, we argue that antibiotic resistance must be viewed as an ecological problem. A fundamental difficulty in assessing the causal relationship between antibiotic use and resistance is the confounding influence of geography: the co-localization of resistant bacterial species with antibiotic use does not necessarily imply causation and could represent the presence of environmental conditions and factors that have independently contributed to the occurrence of resistance. Here, we show how landscape ecology, which links the biotic and abiotic factors of an ecosystem, might help to untangle the complexity of antibiotic resistance and improve the interpretation of ecological studies.

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“…It is believed that drug resistant bacteria from humans and animals, discharged into water bodies, could result in the spread of resistance genes within the bacterial community [3][4][5][6][7]. Therefore, the persistence of antibiotic-resistant intestinal bacteria in water environments, particularly extended-spectrum β-lactamase (ESBL)-producing bacteria, could elicit an important public health risk [8,9].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance and integrons of ESBL-producing thermotolerant coliforms from a water reservoir in Tai'an, China

Zhang

Zhao

Zhai

et al. 2017

J Infect Dev Ctries

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Introduction: The contamination of water environments by extended-spectrum β-lactamases-producing thermotolerant coliforms (ESBL-TC) has aroused public concern. However, little epidemiological data on ESBL-TC isolates from water reservoirs is available in China. Methodology: This study was designed to investigate antibiotic resistance, bla gene types, and the presence of integrons (class 1, 2, and 3) and gene cassettes in ESBL-TC isolated from the Huangqian Reservoir of Tai'an, China. Results: A total of 96 non-duplicate ESBL-TC were obtained in this study and the ESBL genes included blaCTX-M-14 (n = 47), blaCTX-M-15 (n = 27), blaCTX-M-55 (n = 18), blaSHV-12 (n = 4), blaCTX-M-3 (n = 3), and blaCTX-M-123 (n = 1). Eighty-three of the ninety-six ESBL-TC contained class 1 integrons (86.5%), and 2 isolates harbored class 2 integrons. The sizes of gene cassette regions within integrons were ranged from 0.2 kb to 3.2 kb. Conclusions: The findings of this study indicated the widespread presence of ESBL-TC strains in the Huangqian Reservoir and spotlighted the potential role of water bodies as reservoirs for antibiotic resistant genes.

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Environmental selection of antibiotic resistance genes

Cited by 350 publications

References 81 publications

Occurrence of Tylosin-Resistant Enterococci in Swine Manure and Tile Drainage Systems under No-Till Management

Occurrence of Tylosin-Resistant Enterococci in Swine Manure and Tile Drainage Systems under No-Till Management

Erratum: Can landscape ecology untangle the complexity of antibiotic resistance?

Antimicrobial resistance and integrons of ESBL-producing thermotolerant coliforms from a water reservoir in Tai'an, China

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