Environmental specificity of tolerance

Goudie, Andrew J.; Griffiths, Jayne

doi:10.1016/s0166-2236(84)80076-4

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…Not all investigators have reported situational specificity of tolerance and conditional compensatory responding with this preparation. That is, there are reports that such tolerance sometimes is transsituational, rather than situationally specific (i.e., the morphine-experienced rat displays analgesic tolerance in the presence of both drug-paired cues and alternative cues), and sometimes a CCR is not apparent (i.e., rats tolerant to the analgesic effect of morphine do not display heightened sensitivity to nociceptive stimuli—“hyperalgesia”—when presented with morphine-associated cues; e.g., Goudie & Griffiths, 1984; Kesner & Cook, 1983; Sherman, 1979; Tiffany, 1995).…”

Section: Discrepant Findingsmentioning

confidence: 99%

“…Some investigators have suggested that such failures to find results expected on the basis of the conditioning interpretation of tolerance compromise the generality of the theory (see Goudie & Griffiths, 1984; Kesner & Cook, 1983). Others, however, have indicated that apparently contrary findings may be explicable by recognition that there are several potential signals for a drug (in addition to explicit, experimenter-manipulated environmental cues).…”

Section: Discrepant Findingsmentioning

confidence: 99%

“…There are many findings that support the conditioning analysis of tolerance (see reviews by Dworkin, 1993;Ramsay & Woods, 1997;Siegel, in press;Siegel & Allan, 1998). There also are contrary findings (e.g., Bardo & Hughes, 1979;Goudie & Griffiths, 1984;Kesner & Cook, 1983;LaHoste, Olson, Olson, & Kastin, 1980;Tiffany & Maude-Griffin, 1988). The purpose of these experiments was to investigate a basis for the discrepant findings.…”

mentioning

confidence: 97%

See 2 more Smart Citations

Drug-onset cues as signals: Intraadministration associations and tolerance.

Kim¹,

Siegel²,

Patenall³

1999

Journal of Experimental Psychology: Animal Behavior Processes

109

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On the basis of a conditioning analysis of drug tolerance, drug-associated cues become associated with the drug effect. These cues elicit conditional compensatory responses and modulate the expression of tolerance. Although there are many findings consistent with the conditioning analysis of tolerance, there also are contrary findings. The results of these experiments suggest that some of the apparently contradictory findings result because interoceptive pharmacological cues, as well as exteroceptive environmental cues, are paired with a drug effect. That is, within each administration, early drug-onset cues may become associated with the later, larger drug effect, and these pharmacological cues may overshadow simultaneously present environmental cues. We demonstrate the contribution of such intraadministration associations to tolerance to the analgesic effect of morphine and to the expression of conditional compensatory hyperalgesia.

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Section: Discrepant Findingsmentioning

confidence: 99%

Section: Discrepant Findingsmentioning

confidence: 99%

mentioning

confidence: 97%

See 1 more Smart Citation

Drug-onset cues as signals: Intraadministration associations and tolerance.

Kim¹,

Siegel²,

Patenall³

1999

Journal of Experimental Psychology: Animal Behavior Processes

109

View full text Add to dashboard Cite

show abstract

“…Negative results have their place in science, but rarely in a decisive role. Accordingly, it is surprising that in the current debate on the reality of compensatory responses, negative outcomes have been accorded so much weight while positive ones have been discounted (e.g., Baker & Tiffany, 1985; Goudie & Griffiths, 1984).…”

Section: The Case For Conditioned Compensatory Responsesmentioning

confidence: 99%

Homeostatic theory of drug tolerance: A general model of physiological adaptation.

Poulos¹,

Cappell²

1991

Psychological Review

221

148

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At the heart of homeostatic theory is the idea that explicit or implicit behavioral demands placed on physiological systems are required for the biological detection of homeostatic disturbances. The detection of drug-induced disturbances is required to drive the development of all systemic tolerance, both associative and nonassociative (i.e., both forms of tolerance are behaviorally contingent). A wide range of findings ranging from morphine-induced analgesia to ethanol-induced hyposexuality shows that contingent tolerance is pervasive and may be universal. The theory also stipulates that behavioral demands placed on the target system will govern the loss of both associative and nonassociative tolerance (physiological). The present formulation integrates contingent, associative, and nonassociative tolerance and drug-opposite withdrawal reactions within a unified theory.

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“…Opiate receptors are localized in the PAG, and microinjection of morphine or enkephalin into this area also will produce analgesia (Belluzzi et al, 1976;Jacquet & Lajtha, 1973)). Further evidence for a commonality in the substrates for SPA and opiate analgesia comes from the comparable rates at which tolerance develops and their partial crosstolerance (Mayer & Hayes, 1975).Over the past decade, studies from numerous laboratories have demonstrated that tolerance to opiate analgesia is greatly influenced by environmental conditional stimuli (CSs) associated with drug administration (for reviews see Baker & Tiffany, 1985;Goudie & Griffiths, 1984;Siegel, 1983). Specifically, these tolerant responses can be extinguished by repeated presentation of the drug predictive cues alone (MacRae…”

mentioning

confidence: 99%

Associative factors in tolerance to analgesia produced by electrical stimulation in the brainstem.

Paúl

Phillips²

1990

Behavioral Neuroscience

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Tolerance to the analgesic effects of electrical stimulation of the periaqueductal gray was confirmed, and it was demonstrated that this effect was mediated by environmental conditional stimuli (CSs). First, tolerance was extinguished after repeated presentation of CSs in the absence of brain stimulation. Second, environment-specific tolerance was demonstrated. Analgesia was reinstated after brain stimulation in a different test environment. Omission of brain stimulation in the stimulation environment failed to reveal a hyperalgesic response in tolerant Ss. Brain-stimulation analgesia should be beneficial for analyzing neural mechanisms underlying conditioned tolerance to analgesia.

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Environmental specificity of tolerance

Cited by 9 publications

References 19 publications

Drug-onset cues as signals: Intraadministration associations and tolerance.

Drug-onset cues as signals: Intraadministration associations and tolerance.

Homeostatic theory of drug tolerance: A general model of physiological adaptation.

Associative factors in tolerance to analgesia produced by electrical stimulation in the brainstem.

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