Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells
Janine Grolleman,
Nicole C.A. van Engeland,
Minahil Raza
et al.
Abstract:Recent experimental evidence indicates a role for the intermediate filament vimentin in regulating cellular mechanical homeostasis, but its precise contribution remains to be discovered. Mechanical homeostasis requires a balanced bi-directional interplay between the cell its microenvironment and the cellular morphological and mechanical state, this balance being regulated via processes of mechanotransduction and mechanoresponse, commonly referred to as mechanoreciprocity. Here, we systematically analyze viment… Show more
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