Environmental tobacco smoke and breast cancer incidence

Gammon, Marilie D.; Eng, Sybil M.; Teitelbaum, Susan L.; Britton, Julie A.; Kabat, Geoffrey C.; Hatch, Maureen; Paykin, Andrea; Neugut, Alfred I.; Santella, Regina M.

doi:10.1016/j.envres.2003.08.009

Cited by 73 publications

(115 citation statements)

References 40 publications

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“…2000; Kropp and Chang-Claude, 2002) and others showed no effect (Wartenberg et al, 2000;Nishino et al, 2001;Egan et al, 2002;Lash and Aschengrau, 2002;Gammon et al, 2004;Reynolds et al, 2004;Shrubsole et al, 2004;Bonner et al, 2005;Hanaoka et al, 2005;Lissowska et al, 2006). Recent reviews of the literature have also been inconsistent with two showing that there was an association between passive smoking and breast cancer (Johnson, 2005;Miller et al, 2007) and a further two suggesting that more evidence is needed before any conclusions can be drawn (IARC, 2004;US Surgeon General, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…However, only about half of the published studies provided results stratified by menopausal status (Wells, 1991;Millikan et al, 1998;Delfino et al, 2000;Johnson et al, 2000;Gammon et al, 2004;Reynolds et al, 2004;Shrubsole et al, 2004;Bonner et al, 2005;Hanaoka et al, 2005;Lissowska et al, 2006) and therefore the possibility of publication bias cannot be ruled out. The current study adds to the totality of the evidence suggesting that exposure to passive smoking in the home is not associated with an increase in the risk of breast cancer, and does not support the view that there is an increased risk in premenopausal women.…”

Section: Discussionmentioning

confidence: 99%

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Active and passive smoking and the risk of breast cancer in women aged 36–45 years: a population based case–control study in the UK

et al. 2007

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Active smoking has little or no effect on breast cancer risk but some investigators have suggested that passive smoking and its interaction with active smoking may be associated with an increased risk. In a population based case -control study of breast cancer in women aged 36 -45 years at diagnosis, information on active smoking, passive smoking in the home, and other factors, was collected at interview from 639 cases and 640 controls. Women were categorised jointly by their active and passive smoking exposure. Among never smoking controls, women who also reported no passive smoking exposure were significantly more likely to be nulliparous and to be recent users of oral contraceptives. Among those never exposed to passive smoking, there was no significant association between active smoking and breast cancer, relative risk (RR) of 1.12 (95% confidence interval (CI) 0.72 -1.73) for past smokers and RR of 1.19 (95% CI 0.72 -1.95) for current smokers, nor was there an association with age started, duration or intensity of active smoking. Compared with women who were never active nor passive smokers, there was no significant association between passive smoking in the home and breast cancer risk in never smokers, RR of 0.89 (95% CI 0.64 -1.25), in past smokers, RR of 1.09 (95% CI 0.75 -1.56), or in current smokers, RR of 0.93 (95% CI 0.67 -1.30). There was no trend with increasing duration of passive smoking and there was no heterogeneity among any of the subgroups examined. In this study, there was no evidence of an association between either active smoking or passive smoking in the home and risk of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Active and passive smoking and the risk of breast cancer in women aged 36–45 years: a population based case–control study in the UK

et al. 2007

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“…15 This is consistent with findings in the Long Island Breast Cancer Study Project (LIBCSP). 16 However, several studies have suggested that cigarette smoking may increase breast cancer risk among women who have smoked for a long time or before their first fullterm pregnancy. 17;18 An increasing number of studies are also indicating that a positive association between smoking and breast cancer risk may be stronger among or limited to women with certain genotypes.…”

Section: Introductionmentioning

confidence: 99%

Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk

Shen

Gammon

Terry

et al. 2008

European Journal of Cancer

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Xeroderma pigmentosum complementation group C (XPC) is an important DNA nuclear excision repair (NER) gene that recognizes the damage caused by variety of bulky DNA adducts. We evaluated the association of two common non-synonymous polymorphisms in XPC (Ala499Val and Lys939Gln) with breast cancer risk in the Long Island Breast Cancer Study Project (LIBCSP), a population-based case-control study. Genotyping of 1,067 cases and 1,110 controls was performed by a high throughput assay with fluorescence polarization. There were no overall associations between XPC polymorphisms and breast cancer risk. A diplotype CC-CC was significantly associated with increased breast cancer risk compared with diplotype CA-CA (OR = 1.4, 95%CI: 1.0-1.9), but was not significant when compared with all other diplotypes combined (OR = 1.22, 95%CI: 0.97-1.53). No modification effects were observed for XPC genotypes by cigarette smoking status, smoking pack years or polycyclic aromatic hydrocarbons (PAH) DNA adducts. The increase in breast cancer risk was slightly more pronounced among women with detectable PAH-DNA adducts and carrying the diplotype CC-CC (OR = 1.6, 95%CI: 1.1-2.2) compared to women with non detectable PAH-DNA adducts carrying other diplotypes combined, but no statistically significant interaction was observed (P interaction = 0.69). These data suggest that XPC have neither independent effects nor interactions with cigarette smoking and PAH-DNA adducts for breast cancer risk. Further studies with multiple genetic polymorphisms in NER pathway are warranted.

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“…None of these 13 studies showed an overall increase in breast cancer risk associated with second-hand tobacco smoke exposure in Caucasians. The incidence of premenopausal breast cancer was associated with one or more indices of second-hand tobacco smoke exposure in all four studies that stratified the results by menopausal status (Gammon et al, 2004;Shrubsole et al, 2004;Bonner et al, 2005;Slattery et al, 2008) although the association was not always statistically significant (Gammon et al, 2004;Bonner et al, 2005; Fig. 2.1).…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…A total of 16 new studies have been published since the previous IARC Monograph (IARC, 2004). These include three cohort studies (Reynolds et al, 2004;Hanaoka et al, 2005;Pirie et al, 2008) (Table 2.4 available at http://monographs.iarc.fr/ENG/Monographs/vol100E/100E-02-Table2.4.pdf), and 13 new case-control studies (Lash & Aschengrau, 2002;Alberg et al, 2004;Gammon et al, 2004;Shrubsole et al, 2004;Bonner et al, 2005;Sillanpää et al, 2005;Lissowska et al, 2006;Mechanic et al, 2006;Roddam et al, 2007;Rollison et al, 2008;Slattery et al, 2008;Ahern et al, 2009;Young et al, 2009) (Table 2.5 available at http://monographs.iarc.fr/ENG/Monographs/vol100E/100E-02-Table2.5.pdf). Table 2.5 also presents two case-control studies not discussed previously (Zhao et al, 1999;Liu et al, 2000 Pirie et al, 2008;IARC, 2009).…”

Section: Overview Of Studiesmentioning

confidence: 99%

Secondhand Tobacco Smoke

2011

Encyclopedia of Cancer

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Environmental tobacco smoke and breast cancer incidence

Cited by 73 publications

References 40 publications

Active and passive smoking and the risk of breast cancer in women aged 36–45 years: a population based case–control study in the UK

Active and passive smoking and the risk of breast cancer in women aged 36–45 years: a population based case–control study in the UK

Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk

Secondhand Tobacco Smoke

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