Environmentally-Responsive, Entirely Hydrophilic, Shell Cross-linked (SCK) Nanoparticles

Ma, Qinggao; Remsen, Edward E.; Kowalewski, Tomasz; Schaefer, Jacob; Wooley, Karen L.

doi:10.1021/nl0156078

Cited by 78 publications

(74 citation statements)

References 24 publications

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“…The Wooley group has also synthesized an entirely hydrophilic SCK, which was pH responsive. [134] The polymer was poly(acrylic acid)-b-poly-(methyl acrylate), which forms an acrylic acid shell and a methyl methacrylate core micelle. The shell was cross-linked, subsequent hydrolysis of the core using LiOH, which converted acrylate into acid groups, made the entire particle hydrophilic.…”

Section: Block-copolymer Micellesmentioning

confidence: 99%

Soft Nanotechnology with Soft Nanoparticles

2005

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The last decade of research in the physical sciences has seen a dramatic increase in the study of nanoscale materials. Today, "nanoscience" has emerged as a multidisciplinary effort, wherein obtaining a fundamental understanding of the optical, electrical, magnetic, and mechanical properties of nanostructures promises to deliver the next generation of functional materials for a wide range of applications. While this range of efforts is extremely broad, much of the work has focused on "hard" materials, such as Buckyballs, carbon nanotubes, metals, semiconductors, and organic or inorganic dielectrics. Meanwhile, the soft materials of current interest typically include conducting or emissive polymers for "plastic electronics" applications. Despite the continued interest in these established areas of nanoscience, new classes of soft nanomaterials are being developed from more traditional polymeric constructs. Specifically, nanostructured hydrogels are emerging as a promising group of materials for multiple biotechnology applications as the need for advanced materials in the post-genomic era grows. This review will present some of the recent advances in the marriage between water-swellable networks and nanoscience.

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Section: Block-copolymer Micellesmentioning

confidence: 99%

Soft Nanotechnology with Soft Nanoparticles

2005

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“…[93,94] The suitability of crosslinking of the core for applications such as drug delivery purposes has always been questioned. In response, effort were more focused on shell-crosslinking [95][96][97][98] or the crosslinking of the nexus between core-and shell-forming block, typically by employing an ABC triblock copolymer, with block B carrying reactive groups. [99] The crosslinking chemistry ranges from carbodiimide and glutaraldehyde to click chemistry and has been reviewed elsewhere.…”

Section: Micelles From Block Copolymersmentioning

confidence: 99%

Hairy Core–Shell Nanoparticles via RAFT: Where are the Opportunities and Where are the Problems and Challenges?

Stenzel

2009

Macromol. Rapid Commun.

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The preparation of hairy core-shell nanoparticles including (crosslinked) micelles, unimolecular micelles such as star polymers with block structures in each arm and surface grafted nanoparticles such as inorganic particles via the RAFT process are discussed. The RAFT process is certainly a highly versatile process. However, it should not be forgotten that RAFT polymerization is a process, i.e., superimposed on a conventional free radical process. Furthermore, the livingness of the process is dependent on the accessibility of the RAFT group, which can be hampered in certain approaches such as star synthesis and surface grafting from nanoparticles. Nevertheless, the RAFT process is a versatile toolbox that offers good solutions to a range of problems in the preparation of hairy nanoparticles.

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“…[30,31] Covalent crosslinking, either in the core or corona, requires the presence of appropriate reactive functional groups capable of undergoing reactions post-self-assembly. Of these two approaches shell crosslinking has been evaluated widely, especially by Wooley and coworkers, [32][33][34][35][36][37] who pioneered the approach, as well as by Armes et al [19,20,23] Covalent crosslinking of the aggregate core has been less widely evaluated. [14] In the case of the TMP-DMBVA diblock copolymers, the core-shell aggregates formed at high pH contain the DMBVA residues in the core with tertiary amine functional groups that are available for post-assembly modification.…”

Section: Synthesis Of Core Crosslinked Micellesmentioning

confidence: 99%

RAFT Synthesis and Solution Properties of pH‐Responsive Styrenic‐Based AB Diblock Copolymers of 4‐Vinylbenzyltrimethylphosphonium Chloride with N,N‐Dimethylbenzylvinylamine

Lowe

Wang

Tiriveedhi

et al. 2007

Macro Chemistry & Physics

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The RAFT synthesis and solution properties of AB block copolymers of 4‐vinylbenzyltrimethylphosphonium chloride (TMP) and N,N‐dimethylbenzylvinylamine (DMBVA) is described. The pH‐dependent self‐assembly properties of the AB diblock copolymers were examined using of 1H NMR, DLS, and fluorescence spectroscopy. The size of the polymeric aggregates depends on the block copolymer composition/molecular mass. The self assembly is completely reversible, as predicted from the tunable hydrophilicity/hydrophobicity of the DMBVA residues. The AB diblock copolymers can be effectively locked in the self‐assembled state using a straightforward core crosslinking reaction between the tertiary amine residues of DMBVA and difunctional 1,4‐bis(bromomethyl)benzene.magnified image

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Environmentally-Responsive, Entirely Hydrophilic, Shell Cross-linked (SCK) Nanoparticles

Cited by 78 publications

References 24 publications

Soft Nanotechnology with Soft Nanoparticles

Soft Nanotechnology with Soft Nanoparticles

Hairy Core–Shell Nanoparticles via RAFT: Where are the Opportunities and Where are the Problems and Challenges?

RAFT Synthesis and Solution Properties of pH‐Responsive Styrenic‐Based AB Diblock Copolymers of 4‐Vinylbenzyltrimethylphosphonium Chloride with N,N‐Dimethylbenzylvinylamine

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