Envisioning the crosstalk between environmental enrichment and epilepsy: A novel perspective

Akyüz, Enes; Eroğlu, Ece

doi:10.1016/j.yebeh.2020.107660

Cited by 4 publications

(2 citation statements)

References 87 publications

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“…Preclinical studies showed that EE and individual non-pharmacological interventions can reduce epileptic seizures in animal models of epilepsy [286][287][288][289]. EE intervention yielded disease-modifying (antiepileptogenic) effects by delaying an onset of seizures in a rat model of absence epilepsy [288].…”

Section: Epilepsymentioning

confidence: 99%

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Biskupiak,

Ha,

Rohaj

et al. 2024

JCM

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Limitations of pharmaceutical drugs and biologics for chronic diseases (e.g., medication non-adherence, adverse effects, toxicity, or inadequate efficacy) can be mitigated by mobile medical apps, known as digital therapeutics (DTx). Authorization of adjunct DTx by the US Food and Drug Administration and draft guidelines on “prescription drug use-related software” illustrate opportunities to create drug + digital combination therapies, ultimately leading towards drug–device combination products (DTx has a status of medical devices). Digital interventions (mobile, web-based, virtual reality, and video game applications) demonstrate clinically meaningful benefits for people living with Alzheimer’s disease, dementia, rheumatoid arthritis, cancer, chronic pain, epilepsy, depression, and anxiety. In the respective animal disease models, preclinical studies on environmental enrichment and other non-pharmacological modalities (physical activity, social interactions, learning, and music) as surrogates for DTx “active ingredients” also show improved outcomes. In this narrative review, we discuss how drug + digital combination therapies can impact translational research, drug discovery and development, generic drug repurposing, and gene therapies. Market-driven incentives to create drug–device combination products are illustrated by Humira® (adalimumab) facing a “patent-cliff” competition with cheaper and more effective biosimilars seamlessly integrated with DTx. In conclusion, pharma and biotech companies, patients, and healthcare professionals will benefit from accelerating integration of digital interventions with pharmacotherapies.

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Section: Epilepsymentioning

confidence: 99%

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Biskupiak,

Ha,

Rohaj

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…EE has been shown to slow cognitive decline in Alzheimer's disease ( 227 ). To investigate the effects of EE on epilepsy, it was shown that EE can reduce cognitive deficits, increase neural plasticity, improve motor coordination, and reduce the frequency of seizures ( 228 ). We will focus on the effects of EE on information processing mechanisms.…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures

2022

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There has been a major emphasis on defining the role of seizures in the causation of cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative hypothesis behind these deficits, emphasizing the mechanisms of information processing underlying healthy cognition characterized as rate, temporal and population coding. We discuss the role of the underlying etiology of epilepsy in altering neural networks thereby leading to both the propensity for seizures and the associated cognitive impairments. In addition, we address potential treatments that can recover the network function in the context of a diseased brain, thereby improving both seizure and cognitive outcomes simultaneously. This review shows the importance of moving beyond seizures and approaching the deficits from a system-level perspective with the guidance of network neuroscience.

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Flourishing bodies: spiritual entanglements and psychobiological imperatives

Pribac

2023

Religion

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Envisioning the crosstalk between environmental enrichment and epilepsy: A novel perspective

Cited by 4 publications

References 87 publications

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures

Flourishing bodies: spiritual entanglements and psychobiological imperatives

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