Enzymatic and non-enzymatic antioxidant status in stage (III) human oral squamous cell carcinoma and treated with radical radio therapy: Influence of selenium supplementation

Elango, N.; Samuel, Shila; Panneerselvam, Chinnakkannu

doi:10.1016/j.cca.2006.05.021

Cited by 43 publications

(34 citation statements)

References 18 publications

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“…It is an acute phase response protein whose synthesis and secretion can be markedly increased during inflammation, infection, and in diseases such as diabetes, cancer, and cardiovascular disease, as well as during pregnancy (Uriu-Adams and Keen 2005; Elango et al 2006). Our results revealed that ceruloplasmin level in the serum of the control group was markedly increased with respect to the sham group, in the present study.…”

Section: Discussionsupporting

confidence: 45%

Antioxidative role of melatonin in organophosphate toxicity in rats

et al. 2007

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Previous studies revealed that oxidative stress could be an important component of the mechanism of organophosphate (OP) compound toxicity. The aim of the present study was to investigate both prophylactic and therapeutic effects of melatonin against fenthion-induced oxidative stress in rats. Therefore, we determined the changes in the levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the whole blood, brain, pectoral muscle, liver, lung, heart, kidney, pancreas, and jejunum. Also, the changes in the levels of serum nitrite and nitrate, ascorbic acid, retinal, b-carotene, and ceruloplasmin were measured. In addition, activities of enzymatic antioxidants superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in erythrocyte of normal and experimental animals were measured. It was found that fenthion administration increased the levels of MDA in all tissues and decreased or increased the levels of GSH in some tissues. In comparison to nitrate, nitrite and ascorbic acid levels in the serum of experimental groups, there was no significant difference between groups. However, fenthion toxicity led to decrease in retinol and beta-carotene levels; melatonin administration significantly prevented this decrease. Serum ceruloplasmin level was increased due to fenthion administration, but prophylactic and therapeutic melatonin administration inhibited the increase in ceruloplasmin level of serum. There was no significant change in SOD levels in melatonin-administered groups. Melatonin modulates the fenthion-induced changes in the activities of GPx and CAT. In conclusion, the results of the current study revealed that OP toxicity, induced by fenthion, activated oxidant systems in all antioxidant systems in some tissues. Melatonin administration led to a marked increase in antioxidant activity and inhibited lipid peroxidation in most of tissues.

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Section: Discussionsupporting

confidence: 45%

Antioxidative role of melatonin in organophosphate toxicity in rats

et al. 2007

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“…This is well supported by earlier studies on selenium, where no changes were observed in normal peripheral blood mononuclear cells and it did not have any significant effect on either Fas or FasL expression in treated peripheral blood mononuclear cells [28]. Selenium did not induce apoptosis in unstimulated (quiescent) or mitogenically stimulated human peripheral blood mononuclear cells [29] and the combination of selenium with radio therapy and chemo drugs had minimal cytotoxicity normal cells [30]. Genistein in combination with cisplatin and topotecan induced apoptosis in five ovarian cancer cell lines from Stage IIIC disease by increasing the caspase-3 activity [31] and showed that genistein protected normal cells and induced apoptosis in cancer cells [32].…”

Section: Figsupporting

confidence: 84%

An ex vivo study of selenium, genistein on the morphological and nuclear changes in anticancer drug‐induced apoptosis in human peripheral blood lymphocytes

Elango

Usha

2013

BioFactors

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Behavioral difference of cancer cells and normal cells to anticancer drugs is diverse. Debilitating side effects observed with certain chemotherapeutic and prophylactic anticancer drugs have lead to identification of natural agents that may offer protective role against the damage induced in normal cells. The present study aimed to determine the protective role of the micronutrient mineral selenium (Se) and plant product genistein (Gn) in synergy and single, against the apoptosis induced in human peripheral blood lymphocytes by the cytotoxic agents cisplatin and mitomycin C. We observed reduction in apoptotic potential of cisplatin and mitomycin C in lymphocytes by pre-treatment and post-treatment with selenium (30 μM) and genistein (100 μM). The intercellular interaction of Se + Gn in synergy is found to be more efficient in protecting lymphocytes than as individual. Moreover the beneficial results were well pronounced in pre-treatment than in post-treatment condition. The protective action of these natural compounds suggests that they might be useful immunomodulators during the course of chemotherapy and prophylaxis.

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“…Vitamin E protects unsaturated lipid bilayers of cellular and subcellular membranes against ROS mediated oxidative stress (Letchoumy et al, 2007). Vitamin E and GSH inhibited the formation of oral tumors in experimental animals (Elango et al, 2006;Szumilo et al, 2012). Altered status of lipid peroxidation and antioxidants has been shown in oral carcinogenesis (Balakrishnan et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor Initiating Potential of Andrographolide in 7,12-dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis

Manoharan¹,

Singh²,

Suresh³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The aim of the study was to investigate the chemopreventive potential of andrographolide in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors developed in the buccal pouch of golden Syrian hamsters at a 100% incidence on painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Marked abnormalities in the status of detoxification enzymes, lipid perxodiation and antioxidants were noticed in hamsters treated with DMBA alone. Oral administration of andrographolide at a dose of 50 mg/ kg bw to hamsters treated with DMBA not only completely prevented the tumor formation but also restored the status of the above mentioned biomarkers. The present study thus demonstrates the chemopreventive potential of andrographolide in DMBA-induced hamster buccal pouch carcinogenesis, which is probably due to its antioxidant potential as well as modulating effect on xenobiotic metabolising enzymes during DMBA-induced oral carcinogenesis.

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Enzymatic and non-enzymatic antioxidant status in stage (III) human oral squamous cell carcinoma and treated with radical radio therapy: Influence of selenium supplementation

Cited by 43 publications

References 18 publications

Antioxidative role of melatonin in organophosphate toxicity in rats

Antioxidative role of melatonin in organophosphate toxicity in rats

An ex vivo study of selenium, genistein on the morphological and nuclear changes in anticancer drug‐induced apoptosis in human peripheral blood lymphocytes

Anti-tumor Initiating Potential of Andrographolide in 7,12-dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis

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