Enzymatic Component of the Glutathione System in Russian and Buryat Women Depends on the Menopausal Phase

Semenova, Natalya; Brichagina, A. S.; Мадаева, Ирина; Колесникова, Л. И.

doi:10.1134/s0022093022040032

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…In addition, menopause is a risk factor for the oxidative and carbonyl stress devel-opment [19,20]. Antioxidant status changes in blood serum and cells of various organs have been shown in age-related estrogen deficiency [21][22][23] and during respiratory viral infections [24]. It may worsen free radical homeostasis during SARS-CoV-2 infection [4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Semenova,

Vyrupaeva,

Kolesnikov

et al. 2024

Acta biomedica scientifica

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The aim. The research was conducted to assess the total antioxidant and glutathione status, superoxide dismutase activity in menopausal women with moderate and asymptomatic COVID-19.Materials and methods. Ninety two women 45 to 69 years old were divided into groups: women without COVID-19, not vaccinated, with no antibodies to SARS-CoV-2 (IgG) – control; women with moderate COVID-19 – main group; women with anti-SARS-CoV-2 IgG in blood but who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19.Results. A lower glutathione peroxidase (GPx), superoxide dismutase (SOD) activities and a higher glutathione reductase (GR) activity, glutathione S-transferase pi (GSTpi) concentrations were detected in the patients with moderate COVID-19 as compared to control. There were statistically lower oxidized glutathione (GSSG) levels, total antioxidant status (TAS) and higher reduced glutathione (GSH) levels, as well as GSH/GSSG ratio in the group with asymptomatic COVID-19 as compared to control. Significantly a lower GPx, SOD activities and a higher TAS, GR activity, GSTpi concentrations were detected in the patients with symptomatic COVID-19 as compared to group without clinical symptoms. ROC analysis shows the diagnostic significance of TAS (AUC = 0.714; p = 0.048), GSH (AUC = 0.714; p = 0.030), GSSG (AUC = 0.712; p = 0.031), GSH/GSSG (AUC = 0.837; p < 0.001) for group with asymptomatic COVID-19 compared with controls; TAS (AUC = 0.709; p = 0.020), SOD (AUC = 0.760; p < 0.001), GSH/GSSG (AUC = 0.658; p = 0.039), GPx (AUC = 0.774; p < 0.001), GSTpi (AUC = 0.864; p < 0.001) and GR (AUC = 0.871; p < 0.001) for group with moderate COVID-19 compared asympotmatic COVID-19.Conclusions. Antioxidant defense system activity in menopausal women depends on the COVID-19 course.

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Section: Discussionmentioning

confidence: 99%

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Semenova,

Vyrupaeva,

Kolesnikov

et al. 2024

Acta biomedica scientifica

Self Cite

View full text Add to dashboard Cite

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Persistent Post COVID-19 Endothelial Dysfunction and Oxidative Stress in Women

Semenova,

Vyrupaeva,

Kolesnikov

et al. 2024

Pathophysiology

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The assessment of endothelial dysfunction and free radical homeostasis parameters were performed in 92 women, aged 45 to 69 years, divided into the following groups: women without COVID-19 (unvaccinated, no antibodies, control); women with acute phase of COVID-19 infection (main group, COVID-19+); 12 months post COVID-19+; women with anti-SARS-CoV-2 IgG with no symptoms of COVID-19 in the last 12 months (asymptomatic COVID-19). Compared to the control, patients of the main group had lower glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities, decreased advanced glycation end products (AGEs) level, higher glutathione reductase (GR) activity, and higher glutathione S transferases pi (GSTpi), thiobarbituric acid reactants (TBARs), endothelin (END)-1, and END-2 concentrations (all p ≤ 0.05). The group with asymptomatic COVID-19 had lower 8-OHdG and oxidized glutathione (GSSG) levels, decreased total antioxidant status (TAS), and higher reduced glutathione (GSH) and GSH/GSSG levels (all p ≤ 0.05). In the group COVID-19+, as compared to the group without clinical symptoms, we detected lower GPx and SOD activities, decreased AGEs concentration, a higher TAS, and greater GR activity and GSTpi and TBARs concentrations (all p ≤ 0.05). The high content of lipid peroxidation products 12 months post COVID-19+, despite decrease in ENDs, indicates long-term changes in free radical homeostasis. These data indicate increased levels of lipid peroxidation production contribute, in part, to the development of free radical related pathologies including long-term post COVID syndrome.

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Enzymatic Component of the Glutathione System in Russian and Buryat Women Depends on the Menopausal Phase

Cited by 2 publications

References 41 publications

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Menopausal women with moderate and asymptomatic COVID-19: antioxidant defense system biomarkers

Persistent Post COVID-19 Endothelial Dysfunction and Oxidative Stress in Women

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