1965
DOI: 10.1016/0024-3205(65)90118-9
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Enzymatic conversion of serotonin to 5-hydroxytryptophol

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1966
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Cited by 39 publications
(20 citation statements)
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“…They were able to isolate and characterize the glucuronide of 5-hydroxytryptophol as one of the major urinary metabolites of 5HT and suggested that the similar chromatographic behaviour of l'-N-acetyl-5-hydroxytryptamine and 5-hydroxytyptophol led to confusion of the compounds. Feldstein & Wong (1965) showed that rat liver homogenates were capable of converting 5HT into 5-hydroxyindolacetaldehyde, 5HIAA and 5-hydroxytryptophol. They suggested liver as the major site for the conversion of 5HT to 5-hydroxytryptophol.…”
Section: Discussionmentioning
confidence: 99%
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“…They were able to isolate and characterize the glucuronide of 5-hydroxytryptophol as one of the major urinary metabolites of 5HT and suggested that the similar chromatographic behaviour of l'-N-acetyl-5-hydroxytryptamine and 5-hydroxytyptophol led to confusion of the compounds. Feldstein & Wong (1965) showed that rat liver homogenates were capable of converting 5HT into 5-hydroxyindolacetaldehyde, 5HIAA and 5-hydroxytryptophol. They suggested liver as the major site for the conversion of 5HT to 5-hydroxytryptophol.…”
Section: Discussionmentioning
confidence: 99%
“…The alcohol was isolated as conjugates from urine, and distinguished from 1'-N-acetyl 5-hydroxytryptamine by paper chromatography. Feldstein & Wong (1965) demonstrated the enzymatic conversion of 5HT to 5-hydroxytryptophol in rat liver. The alcohol appears also to be a major metabolite of the amine in platelets (Bartholini, Pletscher & Bruderer, 1964).…”
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confidence: 94%
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