Enzymatic Degradation of and Bovine Serum Albumin Release from Starch−Acetate Films

Tuovinen, Laura; Peltonen, Soili; Suortti, Tapani; Crowther, Nicholas J.; Elomaa, Matti; Järvinen, Kristiina

doi:10.1021/bm015581e

Cited by 18 publications

(8 citation statements)

References 21 publications

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“…GG interpenetrating (IPN) network-Natural polysaccharides have been used as colon-specific drug carriers due to their exceptional characteristics. Microbial fermentation in the large intestine could assist in the delivery of drugs by physical and diffusion blockade (Khan et al, 1999;Tuovinen et al, 2002). An interpenetrating network (IPN) system of GG cross-linked with poly (acrylic acid), and polyaniline has been fabricated via radical polymerization using N, N 1 -methylene-bis-acrylamide (MBA) (crosslinker) and ammonium persulfate (initiator) (K. Sharma et al, 2015a).…”

Section: Gt Hydrogel and Electrospun Fibers-mentioning

confidence: 99%

Tree gum-based renewable materials: Sustainable applications in nanotechnology, biomedical and environmental fields

Padil

Wacławek

Černík

et al. 2018

Biotechnology Advances

128

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The prospective uses of tree gum polysaccharides and their nanostructures in various aspects of food, water, energy, biotechnology, environment and medicine industries, have garnered a great deal of attention recently. In addition to extensive applications of tree gums in food, there are substantial non-food applications of these commercial gums, which have gained widespread attention due to their availability, structural diversity and remarkable properties as 'green' bio-based renewable materials. Tree gums are obtainable as natural polysaccharides from various tree genera possessing exceptional properties, including their renewable, biocompatible, biodegradable, and non-toxic nature and their ability to undergo easy chemical modifications. This review focuses on non-food applications of several important commercially available gums (arabic, karaya, tragacanth, ghatti and kondagogu) for the greener synthesis and stabilization of metal/metal oxide NPs, production of electrospun fibers, environmental bioremediation, bio-catalysis, biosensors, coordination complexes of metal-hydrogels, and for antimicrobial and biomedical applications. Furthermore, polysaccharides acquired from botanical, seaweed, animal, and microbial origins are briefly compared with the characteristics of tree gum exudates.

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Section: Gt Hydrogel and Electrospun Fibers-mentioning

confidence: 99%

Tree gum-based renewable materials: Sustainable applications in nanotechnology, biomedical and environmental fields

Padil

Wacławek

Černík

et al. 2018

Biotechnology Advances

128

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“…In addition to the above-mentioned starch blends, attempts have also been made to produce starch and other polysaccharide acetates for medical applications. Starch acetates with degrees of substitution (DS) ranging from 1.9 to 2.6 were made into films and investigated for their potential to release bovine serum albumin (BSA) (Tuovinen et al, 2002). It was reported that acetylation resulted in slower release of BSA.…”

Section: Introductionmentioning

confidence: 99%

Preparation and properties of starch acetate fibers for potential tissue engineering applications

Reddy

Yang

2009

Biotech & Bioengineering

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This article reports the development of fibers from starch acetates that have mechanical properties and water stability better than most polysaccharide-based biomaterials and protein fibers used in tissue engineering. In this research, starch acetates with three different degrees of substitution (DS) have been used to develop fibers for potential use as tissue engineering scaffolds. Varying the DS of starch acetate will provide fibers with different mechanical properties, hydrophilicity, and degradation behavior. Fibers made from DS 2.3 and 2.8 starch acetates have mechanical properties and water stability required for tissue engineering applications. The starch acetate fibers support the adhesion of fibroblasts demonstrating that the fibers would be suitable for tissue engineering and other medical applications.

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“…In this work, SA was chosen because of its wide application in pharmaceutics29–32 as well as its good solubility in organic solvents. The preparations of acetylated starch‐ graft ‐poly( p ‐dioxanone) (SA n ‐PPDO) copolymers were carried out according to the procedures shown in Scheme .…”

Section: Resultsmentioning

confidence: 99%

An efficient approach to synthesize polysaccharides‐graft‐poly(p‐dioxanone) copolymers as potential drug carriers

Fang

Wang

Chen

et al. 2009

J. Polym. Sci. A Polym. Chem.

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Starch and poly(p‐dioxanone) (PPDO) are the natural and synthetic biodegradable and biocompatible polymers, respectively. Their copolymers can find extensive applications in biomedical materials. However, it is very difficult to synthesize starch‐graft‐PPDO copolymers in common organic solvents with very good solubility. In this article, well‐defined polysaccharides‐graft‐poly(p‐dioxanone) (SAn‐PPDO) copolymers were successfully synthesized via the ring‐opening polymerization of p‐dioxanone (PDO) with an acetylated starch (SA) initiator and a Sn(Oct)2 catalyst in bulk. The copolymers were characterized via Fourier transform infrared spectroscopy, 1H NMR, gel permeation chromatography, thermogravimetric analysis (TG), differential scanning calorimetry, and wide angle x‐ray diffraction. The in vitro degradation results showed that the introduction of SA segments into the backbone chains of the copolymers led to an enhancement of the degradation rate, and the degradation rate of SAn‐PPDO increased with the increase of SA wt %. Microspheres with an average volume diameter of 20 μm, which will have potential applications in controlled release of drugs, were successfully prepared by using these new copolymers. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5344–5353, 2009

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Enzymatic Degradation of and Bovine Serum Albumin Release from Starch−Acetate Films

Cited by 18 publications

References 21 publications

Tree gum-based renewable materials: Sustainable applications in nanotechnology, biomedical and environmental fields

Tree gum-based renewable materials: Sustainable applications in nanotechnology, biomedical and environmental fields

Preparation and properties of starch acetate fibers for potential tissue engineering applications

An efficient approach to synthesize polysaccharides‐graft‐poly(p‐dioxanone) copolymers as potential drug carriers

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