Enzymatic degradation of cross-linked high amylose starch tablets and its effect on in vitro release of sodium diclofenac

Rahmouni, Miloud; Chouinard, François; Nekka, Fahima; Lenaerts, Vincent; Leroux, Jean‐Christophe

doi:10.1016/s0939-6411(01)00127-8

Cited by 60 publications

(32 citation statements)

References 14 publications

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“…CLHAS is generally derived from the cross-linking of high amylose starch (70% amylose, 30% amylopectin) with epichlorohydrin or phosphate (Rahmouni et al, 2001). CLHAS tablets are of high drug loading and quasi zero-order release profiles.…”

Section: Cross-linked Starchmentioning

confidence: 99%

“…In the gel state, the V-type single helix in the CLHAS tablets is transformed to the B-type double helix with low cld. (Rahmouni et al, 2001) 3. A gel layer can rapidly form on the surface of the tablets.…”

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

“…High-cld CLHAS is inert to the transition, which will account for the faster and easier water absorption and drug release utilizing high-cld polymers than those utilizing low-cld formulations. ) (Rahmouni et al, 2001 Others 1. The pilot clinical studies confirm that the extended-release properties of CHLAS matrices tablets are not influenced by tablet geometry, compaction pressure and diet.…”

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

“…The hydrolysis rate is closely related to the a-amylase concentration during the initial 2-4 h became independent in the second phase. (Rahmouni et al, 2001) Table 4. Investigations of grafted starch used in extended-release matrix tablets.…”

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

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Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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In recent years, polysaccharides, including starch and its derivatives, have been widely used in the pharmaceutical industry, including as diluents, fillers, binders, disintegrants and glidants. The use of native starch as excipient in extended-release tablets is limited due to its low compactibility and enzymatic degradability, leading to the formation of weakly structured tablets. To overcome these limitations and expand the application of starch as an excipient, researchers have modified starch by physical and chemical methods, as well as by enzymatic hydrolysis. Some starch derivatives, including retrograded starch, pregelatinized starch, carboxymethyl starch, starch acetate, cross-linked starch and grafted starch have recently been introduced as excipients in oral tablets to control drug release. In this review, applications of starch and its derivatives as extended release excipients are reviewed and future frontiers are described.

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Section: Cross-linked Starchmentioning

confidence: 99%

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

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Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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“…The hydrolysis involving enzymes is affected by the process of interaction between enzymes and plastic polymers [17]. All four isolates were esterase and lipase positive (S. Figure 7).…”

mentioning

confidence: 95%

Augmentation of a Microbial Consortium for Enhanced Polylactide (PLA) Degradation

2015

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Bioplastics are eco-friendly and derived from renewable biomass sources. Innovation in recycling methods will tackle some of the critical issues facing the acceptance of bioplastics. Polylactic acid (PLA) is the commonly used and well-studied bioplastic that is presumed to be biodegradable. Considering their demand and use in near future, exploration for microbes capable of bioplastic degradation has high potential. Four PLA degrading strains were isolated and identified as Penicillium chrysogenum, Cladosporium sphaerospermum, Serratia marcescens and Rhodotorula mucilaginosa. A consortium of above strains degraded 44 % (w/w) PLA in 30 days time in laboratory conditions. Subsequently, the microbial consortium employed effectively for PLA composting.Keywords Biodegradability Á Polylactic acid Á Enzymatic degradation Á Microbial degradation As a result of rapid technology growth and global population explosion, the necessity of plastic materials enormously increased in every discipline of life and industries.The increasing accumulation of non-biodegradable synthetic plastics in the environment has been a menace to the earth. The bio-degradable nature of PLA makes it most acceptable to resolve this issue.A very few actinomycetes and thermophilic bacteria such as Brevibacillus, Bacillus smithii, Geobacillus, and Bacillus licheniformis has manifested PLA-degrading ability [1][2][3][4]. Jarerat et al. [5] reported that most of the degraders were restricted to the family Pseudonocardiaceae and related genera such as Saccharothrix, Amycolatopsis, Lentzea, Streptoalloteichus and Kibdelosporangium.PLA biodegradation takes place by the hydrolysis of the ester bonds. The ester linkages in PLA are vulnerable to both chemical hydrolysis and enzymatic cleavage. Microorganisms are devoid of transporters to uptake the plastic polymers directly into the cells due to water insolubility and size of the polymer molecules. The extracellular enzymes secreted by the microbes helps to depolymerize the polymer [6]. An interesting report was that enzymes like Proteinase K secreted by Tritirachium album can degrade PLA [7]. Lee et al. [8] proposed a mechanism of enzymatic degradation for PLA nonwovens fabrics and could be very useful for waste management in the textile industry. Earlier we reported that incorporation of relatively cheap and eco-friendly polymer such as thermoplastic starch, to PLA enhances its biodegradability [9]. The present work intends to demonstrate the rapid biodegradation of PLA by employing a consortium of few new microbial isolates.A commercial grade PLA with molecular weight of 85,000-160,000 was obtained from Sigma-Aldrich (India).Approximately 300 soil samples from different sources (Tropical rain forest areas of Western Ghats of Kerala, composting grounds in local markets, solid waste treatment plant, mangrove soil, activated sludges and dairy sludge Nimisha R. Nair and Vini C. Sekhar have contributed equally to this work. 123Indian J Microbiol (Jan-Mar 2016) 56(1):59-63 DOI 10.1007/s12088-015-0559-z...

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Synthesis, characterization, and enzymatic degradation of starch‐grafted poly(methyl methacrylate) copolymer films

Lee

Cho

2011

J of Applied Polymer Sci

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Graft copolymerization of methyl methacrylate (MMA) onto the corn starch (CS) backbone was carried out in an aqueous medium using ceric ammonium nitrate as an initiator under nitrogen atmosphere. The weight ratio of CS/MMA varied with their composition, as 7/3, 6/4, 5/5, 4/6, and 3/7 were used in this study of the graft efficiency and graft percentage (GP); thus, five different GP CS‐g‐PMMA copolymers were obtained. The molecular weight of CS‐g‐PMMA copolymers were measured by using gel permeation chromatography. The structure of CS and CS‐g‐PMMA copolymer were confirmed by infrared spectra. CS and CS‐g‐PMMA copolymers were characterized by thermal gravimetric analysis, differential scanning calorimetry, and scanning electron microscopy (SEM). Horowitz‐Metzger and Broido methods were applied to investigate the thermal decomposition kinetics of CS‐g‐PMMA copolymers. The effect of GP on the activation energy of decomposition, crystallization behavior, and morphology was investigated. In addition, the biodegradability of CS‐g‐PMMA films were also studied by α‐amylase treatment with different times. The weight loss of CS‐g‐PMMA films after α‐amylase treatment were calculated. Finally, the morphology of CS‐g‐PMMA films before and after α‐amylase treatment were observed by SEM photograph. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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Enzymatic degradation of cross-linked high amylose starch tablets and its effect on in vitro release of sodium diclofenac

Cited by 60 publications

References 14 publications

Recent advances of starch-based excipients used in extended-release tablets: a review

Recent advances of starch-based excipients used in extended-release tablets: a review

Augmentation of a Microbial Consortium for Enhanced Polylactide (PLA) Degradation

Synthesis, characterization, and enzymatic degradation of starch‐grafted poly(methyl methacrylate) copolymer films

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