Enzymatic elimination of substrates flowing through the intact liver

Bass, L.; Keiding, Susanne; Winkler, K.; Tygstrup, Niels

doi:10.1016/0022-5193(76)90026-6

Cited by 150 publications

(55 citation statements)

References 6 publications

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“…The sharp increase in end exhaled air concentrations as the dose rates increase may be caused by a zoning or heterogeneity in the liver and thereby by a concentration gradient in hepatic sinusoid from the postal area to the central vein, which is also seen in other enzyme systems (19). Another possible model is the "parallel-tube" or sinusoidal perfusion model of liver metabolism (20).…”

Section: Discussionmentioning

confidence: 99%

Metabolic interaction between toluene, trichloroethylene and n-hexane in humans

Bælum

Mølhave²,

Hansen³

et al. 1998

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Metabolic interaction between toluene, trichloroethylene and n-hexane in humans

Bælum

Mølhave²,

Hansen³

et al. 1998

Scand J Work Environ Health

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“…CJCi by F and rearranging equation ( 1 ) gives equation (2). Equation (2) indicates that a plot of In F versus R should yield a straight line with intercept equal to -V*,lQK*, and a slope equal to lIQK*,.…”

Section: J G Wagner Et a L mentioning

confidence: 97%

Theoretical decrease in systemic availability with decrease in input rate at steady‐state for first‐pass drugs

Wagner

Antal²,

Elvin³

et al. 1985

Biopharm & Drug Disp

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KEY WORDS Systemic availability Michaelis-Menten kinetics Sinusoidal perfusion modelTHEORETICAL Equation (1) is the general ~n e ' -~ which relates all important variables of the sinusoidal perfusion model for the steady-state situation, where v is the velocity of metabolism of the drug in the liver (masshime), Q is the liver blood flow (volume/time), K*, is the Michaelis constant, C,, is the outlet (venous concentration) of unchanged drug being metabolized, Ci is the inlet (arterial) concentration of drug and V*, is the maximal velocity of metabolism (masshime), V*, and K*, have different numerical values than the corresponding values, V , and K,, of the venous equilibration ('well-stirred') modeL6At steady-state v = R = constant rate of input of the drug (masshime). Also, CJCi is the systemic* availability, F, of the drug.' Replacing v by R and *We are assuming that only hepatic metabolism occurs.

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“…Thus, the zeroth-order approximation for the steady-state leads to a single tube equation, or the tube model (Bass et al, 1976), with the elimination rate k ?T and the #ow velocity v ?T . The solution of eqn (30) is…”

Section: Sinusoidal Interconnections In Hepatic Elimination 439mentioning

confidence: 99%