Enzymatic Hydrolysis of Corn Stover Pretreated by Combined Dilute Alkaline Treatment and Homogenization

Li, Y.; Ruan, Roger; Chen, Paul; Liu, Z.; Pan, Xuejun; Lin, Xiangyang; Liu, Y.; Mok, Chulkyoon; Yang, Tsung Hsun

doi:10.13031/2013.16078

Cited by 148 publications

(122 citation statements)

References 13 publications

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“…In dilute alkaline pretreatment conditions, hemicellulose remains mostly intact with the cellulose fraction (Chandra et al, 2007;Varga et al, 2002); however, some studies have shown that hemicellulose can be solubilized as NaOH concentrations increase. For exam-ple, both Varga et al (2002) and Li et al (2004) found that hemicellulose content in the solid fraction was reduced by more than 60% when pretreating lignocellulose with 10% NaOH. Solubilization of hemicellulose in these more severe pretreatment conditions can also lead to further degradation of sugars into furfural and HMF, two components known for their inhibitory effects on fermentation (Chandra et al, 2007).…”

Section: Changes To Hemicellulosementioning

confidence: 99%

Effects of Sodium Hydroxide Pretreatment on Structural Components of Biomass

2014

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Pretreatment is a unit operation in the conversion of biomass to valuable products that utilizes various combinations of conditions, including chemicals, heat, pressure, and time, to reduce the recalcitrance of lignocellulose. Many such pretreatments have been developed over the years, as the operating conditions can be adapted so that lignocellulose is modified in ways unique to each pretreatment. By tailoring pretreatment conditions to achieve these modifications, the types of final products produced can be controlled. The purpose of this review is to provide a consolidated source of information for sodium hydroxide effects on lignocellulose. The structural characteristics of lignocellulose and the alterations that occur due to the application of sodium hydroxide are detailed. This review also includes a brief description of the chemical reaction mechanism that ensues during the pretreatment. Lastly, the results of studies that utilized sodium hydroxide pretreatment are discussed.

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Section: Changes To Hemicellulosementioning

confidence: 99%

Effects of Sodium Hydroxide Pretreatment on Structural Components of Biomass

2014

Trans.ASABE

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“…Except sorafenib, natural product oleanolic acid inhibited cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway (Xiaofei et al, 2021). As a natural ferroptosis inducer, DHA could react with ferrous ions to produce cytotoxic ROS and played an important role in inducing ferroptosis (Lin et al, 2016;Shen et al, 2020). And in the present study, we reveal the molecular mechanisms that DHA triggered ferritinophagy-dependent ferroptosis in cervical cancer and sensitized to DOX, which may provide novel avenues for future therapy development.…”

Section: Discussionmentioning

confidence: 58%

Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis

Shi

Xiong

Yan

et al. 2023

Front. Mol. Biosci.

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The clinical therapeutics of cervical cancer is limited due to the drug resistance and metastasis of tumor. As a novel target for antitumor therapy, ferroptosis is deemed to be more susceptible for those cancer cells with resistance to apoptosis and chemotherapy. Dihydroartemisinin (DHA), the primary active metabolites of artemisinin and its derivatives, has exhibited a variety of anticancer properties with low toxicity. However, the role of DHA and ferroptosis in cervical cancer remained unclear. Here, we showed that DHA could time-dependently and dose-dependently inhibit the proliferation of cervical cancer cells, which could be alleviated by the inhibitors of ferroptosis rather than apoptosis. Further investigation confirmed that DHA treatment initiated ferroptosis, as evidenced by the accumulation of reactive oxygen species (ROS), malondialdehyde (MDA) and liquid peroxidation (LPO) levels and simultaneously depletion of glutathione peroxidase 4 (GPX4) and glutathione (GSH). Moreover, nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy was also induced by DHA leading to subsequent increases of intracellular labile iron pool (LIP), exacerbated the Fenton reaction resulting in excessive ROS production, and enhanced cervical cancer ferroptosis. Among them, we unexpectedly found that heme oxygenase-1 (HO-1) played an antioxidant role in DHA-induced cell death. In addition, the results of synergy analysis showed that the combination of DHA and doxorubicin (DOX) emerged a highly synergistic lethal effect for cervical cancer cells, which was related also to ferroptosis. Overall, our data revealed the molecular mechanisms that DHA triggered ferritinophagy-dependent ferroptosis and sensitized to DOX in cervical cancer, which may provide novel avenues for future therapy development.

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“…In contrast, potassium treatment down-regulated the expression of these genes. There has been evidence that the combination ABA and PYL can alleviate the inhibition of SnRK2 by PP2C, activate SnRK2, induce plant stress response, and participate in the downstream MAPK signaling pathway (Liu et al, 2022). The expression of all MAPKs in chickpea was significantly increased under abiotic stress (Singh et al, 2017).…”

Section: Potassium Enhances the Salinity Tolerance Of Cotton By Regul...mentioning

confidence: 99%

Weighted gene co-expression network analysis revealed the key pathways and hub genes of potassium regulating cotton root adaptation to salt stress

Sun²,

Xiong³

et al. 2023

Front. Plant Sci.

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Soil salinization is one of the main abiotic stresses affecting cotton yield and planting area. Potassium application has been proven to be an important strategy to reduce salt damage in agricultural production. However, the mechanism of potassium regulating the salt adaptability of cotton has not been fully elucidated. In the present research, the appropriate potassium application rate for alleviating salt damage of cotton based on different K+/Na+ ratios we screened, and a gene co-expression network based on weighted gene co-expression network analysis (WGCNA) using the transcriptome data sets treated with CK (0 mM NaCl), S (150 mM NaCl), and SK8 (150 mM NaCl + 9.38 mM K2SO4) was constructed. In this study, four key modules that are highly related to potassium regulation of cotton salt tolerance were identified, and the mitogen-activated protein kinase (MAPK) signaling pathway, tricarboxylic acid (TCA) cycle and glutathione metabolism pathway were identified as the key biological processes and metabolic pathways for potassium to improve cotton root salt adaptability. In addition, 21 hub genes and 120 key candidate genes were identified in this study, suggesting that they may play an important role in the enhancement of salt adaptability of cotton by potassium. The key modules, key biological pathways and hub genes discovered in this study will provide a new understanding of the molecular mechanism of potassium enhancing salinity adaptability in cotton, and lay a theoretical foundation for the improvement and innovation of high-quality cotton germplasm.

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Enzymatic Hydrolysis of Corn Stover Pretreated by Combined Dilute Alkaline Treatment and Homogenization

Cited by 148 publications

References 13 publications

Effects of Sodium Hydroxide Pretreatment on Structural Components of Biomass

Effects of Sodium Hydroxide Pretreatment on Structural Components of Biomass

Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis

Weighted gene co-expression network analysis revealed the key pathways and hub genes of potassium regulating cotton root adaptation to salt stress

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