Enzymatic O-Methylation of Epinephrine and Other Catechols

Axelrod, Julius; Tomchick, Robert

doi:10.1016/s0021-9258(18)64731-3

Cited by 1,217 publications

(127 citation statements)

References 16 publications

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“…[2][3][4] Val158Met (Ex4-12 G>A; rs4680) is a common polymorphism that results in a lower activity enzyme. 5 The low-activity Met allele has been positively associated with breast cancer in some, but not all, studies. [6][7][8] The present study evaluated the relation between COMT Val158Met and uterine fibroids in premenopausal women, which are common, benign estrogen-responsive tumors that were positively associated with the Val/Val genotype in a recent study.…”

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Val153Met Polymorphism of Catechol-O-Methyltransferase and Prevalence of Uterine Leiomyomata

et al. 2007

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The catechol-O-methyltransferase (COMT) gene encodes enzymes that inactivate catechol estrogens and may have a protective role in estrogen-induced tumorigenesis, such as uterine leiomyoma (fibroids). Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G>A; rs4680) that results in a lower activity enzyme, increasing susceptibility to tumorigenesis. The purpose of this study was to evaluate the relation between the COMTVal158Met polymorphism and uterine fibroids. Participants were 972 premenopausal African American (n = 576) and white (n = 396) women from a cross-sectional sample of women in the National Institute of Environmental Health Science's Uterine Fibroid Study. Blood was collected from participants for DNA, and telephone interviews and questionnaires were completed to gather demographic and reproductive history. Prevalence ratios and 95% confidence intervals were estimated using race-specific log-risk regression models. Effect measure modification by age, body mass index, oral contraceptive use, full-term births, smoking, and alcohol use were also evaluated. Distributions of genotypes and fibroid prevalence varied by race. No associations between fibroids and Val158Met were observed among African American or white participants. This study suggests that variation in this polymorphism alone does not affect fibroid prevalence. Additional research is needed to examine other variations and haplotypes within the COMT gene.

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Val153Met Polymorphism of Catechol-O-Methyltransferase and Prevalence of Uterine Leiomyomata

et al. 2007

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“…44 COMT functions as a methyltransferase that mediates methyl group transfer from S-adenosylmethionine to catecholamines, including neurotransmitters like dopamine, 45 which can result in catecholamine transmitter degradation. 46 A total of 11 COMT transcripts have been described in GTEx 47 with transcripts ENST00000467943.1 and ENST00000406520.3 having nearly ubiquitous and high levels of expression across the 53 human body tissues analyzed.…”

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Genetic associations of perinatal pain and depression

et al. 2019

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Underlying genetic influences may affect perinatal pain, depression, or both. We investigated the role of 59 single-nucleotide polymorphisms on 20 quantitative traits measured in perinatal women. Moreover, 183 pregnant women (28–37 weeks’ gestation) were prospectively genotyped for single-nucleotide polymorphisms with known prior associations with either pain or depression in nonpregnant populations. Prenatal saliva samples were collected. Phenotypic data were gathered during prenatal, labor and delivery, and postpartum (six weeks and three months) periods, capturing labor pain, Edinburgh Postnatal Depression Score, and Brief Pain Inventories. Following quality control, genotypes were used as predictors and phenotypes as dependent variables in multiple linear regression analyses to detect associations. Three statistical models were tested: additive allele effects, deviation from dominant allele effects, and the joint test of both. rs4633 (a synonymous single-nucleotide polymorphism in COMT) associated with “pain right now” scores at six weeks postpartum. Single-nucleotide polymorphisms rs1135349 (a single-nucleotide polymorphism within a small noncoding RNA that has many prior associations for depression) and rs7548151 (intronic in ASTN1) were associated with the maximum pain unpleasantness score experienced during labor (a measure of the emotional valence of labor pain), controlling for the Holm–Bonferroni family-wise error rate. Sensory dimensions of labor pain (i.e., pain intensity) and postpartum depression scores were not associated with genotyped single-nucleotide polymorphisms. Identifying genomic components of these perinatal complex disorders may produce insights into relevant pathways or novel treatment options.

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“…Ή παρουσία της S-άδενοσυλμεθειονίνης, ώς δότου της μεθυλομάδος 104 , ι 33 καί δισθενοΰς μεταλλικού ιόντος, συνήθως Mg ++l04 ,i 34 είναι απαραίτητος δια την δρασιν τοΰ ένζυ μου. Ύττ' άλλων ερευνητών διεπιστώθη ή αναστολή της δράσεως τοΰ εν ζύμου υπό τοΰ π-χλωροβενζοϊκοΰ οξέος καί ίωδικοΰ οξέος 104 , ενώσεων δεσμευουσών τήν σερίνην, υπό τοΰ καλομέλανος ι 35 , δεσμεύοντος τάς σουλφυδρυλικάς ομάδας, υπό της πυρογαλλόλης 109 , 120 , ' 21 , ' 25 , των πολυφαινολών ' 36 , της όξυκινολίνης 125 , των εστέρων τοΰ γαλλικού οξέος 125 κ.τ.λ. ουσιών, δρωσών ώς ανταγωνιστών των κατεχολαμινών (αδρενα λίνης καί νοραδρεναλίνης) δια τήν άποδοχήν της μεθυλομάδος.…”

Section: άποκαρβοξυλίωσιςunclassified

“…Αναφέρεται καί μία περίπτωσις μετρήσεως της δραστικότητος είς το δέρμα 124 . Μόνον ô Axelrod 104 δίδει μίαν τιμήν της δραστικότητος τοΰ ενζύμου είς δείγμα ήπατος άνθρωπου, φυλαχθέν όμως έπί τρεις μήνας είς θερμοκρασίαν-10° C προ τής μετρήσεως. Ουδέν έτερον στοιχεϊον, άφορων είς τήν δραστικότητα τής κατεχόλ-Ο-μεθυλτρανσφεράσης εις νωπά δείγμα-τα ήπατος άνθρωπου κοά δη sis τ « διάφορα στάδια αναπτύξεως αύτοϋ, άνεύρομεν εις την προσιτήν εις ήμας διεθνή βιβλιογραφίαν.…”

Section: άποκαρβοξυλίωσιςunclassified

“…Τεχνική προσδιορισμού. Ή χρησιμοποιηθείσα τεχνική ήτο ή περιγραφόμενη υπό του Axelrod 104 με τροποποίησιν, όσον άφορα τον προσδιορισμον τών μετακατεχολαμίνων, συμφώνως προς τήν μέθοδον τών Grout 14 3 και Pissano 144 . Έχει δέ ως έξης: Είς 1 κ. εκ.…”

Section: γ κατεχολ-ο-μεθυλ-τρανσφερασμunclassified

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Ο Μεταβολισμος Της Τυροσινης Κατα Την Αναπτυξιν Του Ανθρωπου

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Enzymatic O-Methylation of Epinephrine and Other Catechols

Cited by 1,217 publications

References 16 publications

Val153Met Polymorphism of Catechol-O-Methyltransferase and Prevalence of Uterine Leiomyomata

Val153Met Polymorphism of Catechol-O-Methyltransferase and Prevalence of Uterine Leiomyomata

Genetic associations of perinatal pain and depression

Ο Μεταβολισμος Της Τυροσινης Κατα Την Αναπτυξιν Του Ανθρωπου

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