Enzymatic Ring-Opening Polymerization and Atom Transfer Radical Polymerization from a Bifunctional Initiator

Recent Developments in Lipase‐Catalyzed Synthesis of Polyesters

“…Second, Sn-catalyzed ROP of lactide was initiated from 2-, 3-and 4-OH groups to give a copolymer consisting of one poyl(e-CL) arm with M n ¼ 1 300 and three PLA arms, with M n of the final product ¼ 11 500 (Scheme 20). [98] A new chemoenzymatic method was developed [99] utilizing the enzyme (lipase)-catalyzed ring-opening polymerization (eROP) of lactones and atom transfer radical polymerization (ATRP). [100] The combination of two different, consecutively-proceeding polymerization reactions is referred to as cascade polymerization.…”

Enzymatic Control of the Size of DNA Block Copolymer Nanoparticles

“…[26][27][28] One block was generated by atom-transfer radical polymerization, and the other block was synthesized by lipases, producing polyester segments. These block copolymers were characterized regarding their chemical composition but a further analysis of the aggregation behavior of these materials was not undertaken.…”

Chemoenzymatic synthesis of an AB‐type diblock copolymer combining enzymatic self‐condensation polymerization and atom transfer radical polymerization

“…This strategy has motivated more researchers to study the chemoenzyme-catalyzed route to block copolymer synthesis. 12,13 For instance, Heise et al 12 reported the first example of the chemoenzymatic synthesis of the ABtype diblock copolymer polycaprolactone-block-polystyrene from a dual initiator on the basis of the integration of biocatalytic polymerization (i.e., enzymatic ROP of -caprolactone) and traditional living/controlled radical polymerization 14 [i.e., atom transfer radical polymerization (ATRP) 15 of styrene]. Our group used another synthetic pathway 13 to prepare block copolymers with the same structure.…”