Enzymatic synthesis of chiral alcohols using ketoreductases

Yuan, Quan; Ma, Li; Kong, Weixi; Liu, Jianqiao; Zhang, Shuling; Yan, Jiajing; Bai, Jing; He, Ying; Zhou, Liya; Liu, Yunting; Jiang, Yanjun

doi:10.1080/01614940.2024.2313603

Catalysis Reviews

2024

DOI: 10.1080/01614940.2024.2313603

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Enzymatic synthesis of chiral alcohols using ketoreductases

Quan Yuan,

Li Ma,

Weixi Kong

et al.

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2024

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Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones

Sándor,

Csuka,

Poppe

et al. 2024

Molecules

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This study explored the enantiocomplementary bioreduction in substituted 1-(arylsulfanyl)propan-2-ones in batch mode using four wild-type yeast strains and two different recombinant alcohol dehydrogenases from Lactobacillus kefir and Rhodococcus aetherivorans. The selected yeast strains and recombinant alcohol dehydrogenases as whole-cell biocatalysts resulted in the corresponding 1-(arylsulfanyl)propan-2-ols with moderate to excellent conversions (60–99%) and high selectivities (ee > 95%). The best bioreductions—in terms of conversion (>90%) and enantiomeric excess (>99% ee)—at preparative scale resulted in the expected chiral alcohols with similar conversion and selectivity to the screening reactions.

show abstract

Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones

Sándor,

Csuka,

Poppe

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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Enzymatic synthesis of chiral alcohols using ketoreductases

Cited by 1 publication

References 207 publications

Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones

Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones

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