Enzymatic synthesis of flavonoid glucosides and their biochemical characterization

Nguyen, Thi Thanh Hanh; Jin, Juhui; Septiana, Iis; Quereshi, Dilshad; Pal, Kunal; Kim, Doman

doi:10.1016/b978-0-12-816897-4.00002-3

Cited by 1 publication

(1 citation statement)

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“…Genistin ( 32 ), a chemoprotective isoflavone abundant in soybeans together with glycitin ( 33 ) and daidzin ( 34 ), was also isolated from the stem vines of these two species (Gong et al 2014 ; Ye et al 2012a , b ). Glycosylation is one of the most important factors considered in modifying the solubility, bioavailability, and therapeutic potential of bioactive molecules of synthetic and natural origin (Hanh et al 2020 ; Szeja et al 2017 ). As a result, the synthesis of glycosylated isoflavones has long been a research focus (Szeja et al 2017 ).…”

Section: Structural Diversity Of Millettia Isoflav...mentioning

confidence: 99%

Millettia isoflavonoids: a comprehensive review of structural diversity, extraction, isolation, and pharmacological properties

Desta

El‐Aty

2022

Phytochem Rev

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There are approximately 260 known species in the genus Millettia , many of which are used in traditional medicine to treat human and other animal ailments in various parts of the world. Being in the Leguminosae (Fabaceae) family, Millettia species are rich sources of isoflavonoids. In the past three decades alone, several isoflavonoids originating from Millettia have been isolated, and their pharmacological activities have been evaluated against major diseases, such as cancer, inflammation, and diabetes. Despite such extensive research, no recent and comprehensive review of the phytochemistry and pharmacology of Millettia isoflavonoids is available. Furthermore, the structural diversity of isoflavonoids in Millettia species has rarely been reported. In this review, we comprehensively summarized the structural diversity of Millettia isoflavonoids, the methods used for their extraction and isolation protocols, and their pharmacological properties. According to the literature, 154 structurally diverse isoflavonoids were isolated and reported from the various tissues of nine well-known Millettia species. Prenylated isoflavonoids and rotenoids were the most dominant subclasses of isoflavonoids reported. Other subclasses of reported isoflavonoids include isoflavans, aglycone isoflavones, glycosylated isoflavones, geranylated isoflavonoids, phenylcoumarins, pterocarpans and coumaronochromenes. Although some isolated molecules showed promising pharmacological properties, such as anticancer, anti-inflammatory, estrogenic, and antibacterial activities, others remained untested. In general, this review highlights the potential of Millettia isoflavonoids and could improve their utilization in drug discovery and medicinal use processes. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-022-09845-w.

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