Enzymatically derived oil-based L-ascorbyl esters: Synthesis, antioxidant properties and controlled release from cosmetic formulations

Ćorović, Marija; Milivojević, Ana; Simović, Milica; Banjanac, Katarina; Pjanović, Rada; Bezbradica, Dejan

doi:10.1016/j.scp.2020.100231

Cited by 27 publications

(25 citation statements)

References 31 publications

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“…The n value of 0.5 and 1 corresponds to a Fickian diffusion and polymer relaxation (Case II transport), respectively. The combined effect of these two types of transport mechanisms is non-Fickian diffusion, and in this case, the exponent n has a value between 0.5 and 1 [19,27]. If there is the lag time (t lag ) before the diffusion starts, the modified form of Equation 1 is used:…”

Section: Calculation Of the Effective Diffusion Coefficientsmentioning

confidence: 99%

“…They differ from each other in the proportion of water and oil phase, which can have a distinct effect on the dermal and transdermal diffusion of incorporated components [18]. The Franz diffusion cells are widely used methodology for in vitro revealing mechanism of release of different active ingredients from topical formulations [19]. This type of cell is generally employed in diffusion studies because of its simplicity, the low amount of drug required for analysis and the easy control of experimental conditions [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Prebiotic effect of galacto‐oligosaccharides on the skin microbiota and determination of their diffusion properties

Petrov

Ćorović

Milivojević

et al. 2022

Intern J of Cosmetic Sci

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Objective: Recently, prebiotics are attracting plenty of attention in the field of skin care, since it is found that they are able to support the balance of beneficial and harmful microorganisms on the skin, and accordingly prevent several skin conditions associated with microbial imbalance. Topical application of prebiotics, although insufficiently investigated, holds great promise in improving skin health. The purpose of this research was to determine the prebiotic potential of galacto-oligosaccharides (GOS) for skin microbiota and suitability for incorporation in different topical formulations, and finally, provide insights into their diffusion properties. Methods:The prebiotic effect of GOS was evaluated through the influence on the growth of Staphylococcus epidermidis and Staphylococcus aureus, the most common resident and pathogenic bacterium of the skin microbiota, respectively. Also, with the future use of GOS in cosmetic products in mind, the diffusion of GOS molecules from two different topical formulations, hydrogel and oil-inwater (O/W) gel emulsion, was monitored employing Franz diffusion cell and two systems-with cellulose acetate membrane and transdermal diffusion test model, Strat-M® membrane. Course of fermentation and the amount of diffused GOS molecules were monitored using high-performance liquid chromatography (HPLC). Results:The in vitro results revealed that GOS at a concentration of 5% (w/v) has a pronounced stimulatory effect on S. epidermidis, while simultaneously showing an inhibitory effect on S. aureus, both in nutrient broth and cosmetic formulations. GOS trisaccharide and tetrasaccharide diffusion coefficients from O/W gel emulsion were calculated to be 5.61•10 −6 cm 2 s −1 and 1.41•10 −8 cm 2 s −1 , respectively. The diffusion coefficient of GOS trisaccharides from hydrogel was 3.22•10 −6 cm 2 s −1 , while it was not determined for tetrasaccharides due to low diffused concentration. Transdermal diffusion tests revealed that GOS incorporated in two formulations stays at the surface of the skin even after 24 h. Conclusion:When applied in adequate concentration, GOS has the potential to be used as a skin prebiotic. Novel GOS enriched formulations, Aristoflex® PREBIOTIC EFFECT OF GALACTO-OLIGOSACCHARIDES ON THE SKIN MICROBIOTA AND DETERMINATION OF THEIR DIFFUSION PROPERTIES Conclusion: Lorsqu'il est appliqué à une concentration adéquate, le GOS a le potentiel d'être utilisé comme prébiotique cutané. De nouvelles formulations enrichies en GOS, l'hydrogel à base d'Aristoflex® AVC et l'émulsion de gel H/E à base d'Heliogel™, ont permis une diffusion et une délivrance efficaces des molécules GOS prébiotiques à la surface de la peau.

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Section: Calculation Of the Effective Diffusion Coefficientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prebiotic effect of galacto‐oligosaccharides on the skin microbiota and determination of their diffusion properties

Petrov

Ćorović

Milivojević

et al. 2022

Intern J of Cosmetic Sci

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“…The use of soapstock as a source of FFAs for the synthesis of fine chemicals is to be further investigated to expand the variety of products that can be obtained. The possibility to prepare other biodegradable surfactants [83], monomers for bio-based biodegradable new-generation polymers [84,85], and additives for the cosmetic industry [86][87][88] has to be carefully investigated.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Enzymatic Methods for the Manipulation and Valorization of Soapstock from Vegetable Oil Refining Processes

Casali

Brenna

Parmeggiani

et al. 2021

Sustainable Chemistry

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The review will discuss the methods that have been optimized so far for the enzymatic hydrolysis of soapstock into enriched mixtures of free fatty acids, in order to offer a sustainable alternative to the procedure which is currently employed at the industrial level for converting soapstock into the by-product known as acid oil (or olein, i.e., free fatty acids removed from raw vegetable oil, dissolved in residual triglycerides). The further biocatalyzed manipulation of soapstock or of the corresponding acid oil for the production of biodiesel and fine chemicals (surfactants, plasticizers, and additives) will be described, with specific attention given to processes performed in continuous flow mode. The valorization of soapstock as carbon source in industrial lipase production will be also considered.

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“…Lipases have a great affinity with a wide range of substrates, high stability to temperature, pH, and organic solvents, and can be chemoselective, regioselective and enantioselective (BARROS; FLEURI; MACEDO, 2010; GOLUNSKI et al, 2016). Due to these features and the ability to catalyze hydrolysis and synthesis reactions, lipases have been used in several applications in the pharmaceutical, food, chemical and cosmetic industries, in the formulation of detergents and the production of biodiesel (ALMEIDA et al, 2019;BOROWIECKI;DRANKA, 2019;ĆOROVIĆ et al, 2020;JAHANGIRI et al, 2018;MURILLO et al, 2019;PHUKON et al, 2020). Lipases can be produced from microorganisms (bacteria or fungi), plants (mainly from seeds and latex), and animals (pancreatic, hepatic or gastric lipases).…”

Section: Lipasesmentioning

confidence: 99%

Valorization and Treatment of Oily Wastewaters From Agro-Industries Using Lipases: An Overview

Mulinari¹,

Júnior²,

Oliveira³

et al. 2020

Ciência, Tecnologia E Inovação: Do Campo À Mesa

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Oily wastewater from agro-industries can cause severe environmental and public health damages if unproperly treated. The conventional methods have several limitations for the treatment of oily wastewaters since the oil fraction can cause pipe clogging and biomass washout during the biological step. Based on this, the use of lipases can increase the oil removal efficiency of the treatments, minimizing operational problems, and improving the performance of the biological process. Lipases can also be used for the valorization of the oily wastewaters, transforming these waste streams into valuable compounds, such as biodiesel, lubricants, antioxidant agents, etc. The use of wastes for the production of value-added compounds follows the circular economy approach, minimizing the generation of residues and potential environmental liabilities. Thus, this study aims to give a general overview of the main topics related to the treatment and valorization of oily wastewaters using lipases. The main characteristics of oily wastewaters from agro-industries are addressed, as well as the most used conventional techniques for their treatment. Some relevant information about the enzyme lipase is also discussed to give the reader a background about how these enzymes can be applied for the treatment and transformation of oily wastes.

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Enzymatically derived oil-based L-ascorbyl esters: Synthesis, antioxidant properties and controlled release from cosmetic formulations

Cited by 27 publications

References 31 publications

Prebiotic effect of galacto‐oligosaccharides on the skin microbiota and determination of their diffusion properties

Prebiotic effect of galacto‐oligosaccharides on the skin microbiota and determination of their diffusion properties

Enzymatic Methods for the Manipulation and Valorization of Soapstock from Vegetable Oil Refining Processes

Valorization and Treatment of Oily Wastewaters From Agro-Industries Using Lipases: An Overview

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