Enzymatically-mineralized double-network hydrogels with ultrahigh mechanical strength, toughness, and stiffness

Wang, Li; Zhao, Wei; Zhao, Yuhai; Li, Wei; Wang, Guodong; Zhang, Qiang

doi:10.7150/thno.77417

Cited by 12 publications

(6 citation statements)

References 53 publications

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“…Recently, enzymatic mineralization has been emerging as a way to efficiently carry out the assembly of mineralized nanostructures. [ 74–78 ] This method uses homogeneously dispersed enzymes that either increase pH value to induce mineral formation or convert precursor molecules into active mineralization compounds, resulting in indirectly induced mineralization. The increase in pH value facilitates the spontaneous mineralization process on the polymer matrix by enhancing the activity of OH − in the solution.…”

Section: Construction Of Mineralization Nanostructure In Polymersmentioning

confidence: 99%

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Lv,

Wang,

Zhang

2024

Small

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Mineralization capable of growing inorganic nanostructures efficiently, orderly, and spontaneously shows great potential for application in the construction of high‐performance organic–inorganic composites. As a thermodynamically spontaneous solid‐phase crystallization reaction involving dual organic and inorganic components, mineralization allows for the self‐assembly of sophisticated and exclusive nanostructures within a polymer matrix. It results in a diversity of functions such as enhanced strength, toughness, electrical conductivity, selective permeability, and biocompatibility. While there are previous reviews discussing the progress of mineralization reactions, many of them overlook the significant benefits of interfacial regulation and functionalization that come from the incorporation of mineralized structures into polymers. Focusing on different means of assembly of mineralized nanostructures in polymer, the work analyzes their design principles and implementation strategies. Then, their different advantages and disadvantages are analyzed by combining nanostructures with organic substrates as well as involving the basis of different functionalizations. It is anticipated to provide insights and guidance for the future development of mineralized polymer composites and their application designs.

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Section: Construction Of Mineralization Nanostructure In Polymersmentioning

confidence: 99%

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Lv,

Wang,

Zhang

2024

Small

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“…In later studies, soft lithography has been used to precisely control the surface morphology of hydrogels, achieving linear surface roughness variation from nanometer to micrometer on a stiffness controllable matrix 14 , 20 . Ultrahigh strength and high stiffness of hydrogels can also be developed through a brick-mortar-like network that composed of bacterial cellulose nanofibers and alginate-Ca 2+ 24 , or forming a hybrid scaffold with 3D PCL/nano-hydroxyapatite (nHA) scaffold 25 . Macro-porous recombinant elastin-like protein substrates 4 and the combination of alginate and gelatin for bioprinting 26 are promising for the optimization of stiffness as well.…”

Section: Biomaterials-induced Physicomechanical Stimuli Towards Mscsmentioning

confidence: 99%

Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Shi¹,

Zhou²,

Wang³

et al. 2023

Theranostics

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Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the most promising alternative to avoid the drawbacks of autograft and allograft bone. Nevertheless, how to precisely control stem cell osteogenic differentiation has been a long-standing puzzle. Compared with biochemical cues, physicomechanical stimuli have been widely studied for their biosafety and stability. The mechanical properties of various biomaterials (polymers, bioceramics, metal and alloys) become the main source of physicomechanical stimuli. By altering the stiffness, viscoelasticity, and topography of materials, mechanical stimuli with different strengths transmit into precise signals that mediate osteogenic differentiation. In addition, externally mechanical forces also play a critical role in promoting osteogenesis, such as compression stress, tensile stress, fluid shear stress and vibration, etc. When exposed to mechanical forces, mesenchymal stem cells (MSCs) differentiate into osteogenic lineages by sensing mechanical stimuli through mechanical sensors, including integrin and focal adhesions (FAs), cytoskeleton, primary cilium, ions channels, gap junction, and activating osteogenic-related mechanotransduction pathways, such as yes associated proteins (YAP)/TAZ, MAPK, Rho-GTPases, Wnt/β-catenin, TGFβ superfamily, Notch signaling. This review summarizes various biomaterials that transmit mechanical signals, physicomechanical stimuli that directly regulate MSCs differentiation, and the mechanical transduction mechanisms of MSCs. This review provides a deep and broad understanding of mechanical transduction mechanisms and discusses the challenges that remained in clinical translocation as well as the outlook for the future improvements.

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“…Mouse skin organoid model was made according to the previous article 53 . Neonatal mice born within 24 hours were selected and sacri ced by cervical dislocation.…”

Section: Mouse Skin Organoid Culturementioning

confidence: 99%

Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia

Li,

duan,

cheng

et al. 2023

Preprint

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Androgenetic alopecia (AGA) is a prevalent hair loss disorder characterized by an unclear pathogenesis mechanism and limited therapeutic efficacy. Despite a growing body of evidence indicating a link between AGA and metabolic disorders, the precise role of metabolism in AGA development remains elusive. In this study, we employed targeted metabolome profiling to identify distinct metabolic signatures in AGA patients, with a particular focus on amino acid-related metabolic pathways. Notably, our findings highlight a significant decrease in serum abundance of arginine in AGA patients.Locally, impaired arginine metabolism in hair follicles (HFs) experiencing balding was assumed, as evidenced by the heightened expression of ARG1, the pivotal enzyme regulating the arginine-ornithine transition, and the diminished expression of the arginine transporter SLC7A1. Our study further demonstrated that arginine deficiency hinders human hair growth by antagonizing the mTOR signaling pathway. Moreover, the administration of arginine effectively safeguards against the inhibition of hair growth induced by DHT in an AGA-like mouse model and in balding HFs obtained from AGA patients.Collectively, these findings reveal that obstruction of anagen maintenance cause by arginine deficiency occurs in AGA patients and raise the possibility of supplementation with arginine as a promising clinical treatment strategy.

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Enzymatically-mineralized double-network hydrogels with ultrahigh mechanical strength, toughness, and stiffness

Cited by 12 publications

References 53 publications

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Construction of Mineralization Nanostructures in Polymers for Mechanical Enhancement and Functionalization

Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia

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