Enzymatische Inaktivierung von Isonicotins�urehydrazid im menschlichen und tierischen Organismus

Bönicke, R.; Reif, W

doi:10.1007/bf00246110

Cited by 79 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…110 This drug is primarily excreted following acetylation catalysed by NAT2. Since then, many therapeutic agents have been shown to be polymorphically acetylated in humans.…”

Section: Nat and Drug Responsementioning

confidence: 99%

Pharmacogenetics of the arylamine N-acetyltransferases

et al. 2002

View full text Add to dashboard Cite

The arylamine N-acetyltransferases (NATs) are involved in the metabolism of a variety of different compounds that we are exposed to on a daily basis. Many drugs and chemicals found in the environment, such as those in cigarette smoke, car exhaust fumes and in foodstuffs, can be either detoxified by NATs and eliminated from the body or bioactivated to metabolites that have the potential to cause toxicity and/or cancer. NATs have been implicated in some adverse drug reactions and as risk factors for several different types of cancers. As a result, the levels of NATs in the body have important consequences with regard to an individual's susceptibility to certain druginduced toxicities and cancers. This review focuses on recent advances in the molecular genetics of the human NATs.

show abstract

“…110 This drug is primarily excreted following acetylation catalysed by NAT2. Since then, many therapeutic agents have been shown to be polymorphically acetylated in humans.…”

Section: Nat and Drug Responsementioning

confidence: 99%

Pharmacogenetics of the arylamine N-acetyltransferases

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Monitoring of sulfonamides blood levels had come into vogue in the late 1930s and early 1940s as a means to ensure effective antibacterial therapy; continuation of this practice with the newly discovered antituberculosis drug isoniazid in 1953 led to the recognition of inter-individual differences in the metabolic fate of the drug. 3 Hughes et al4 identified the metabolites and matched individual metabolizing capacity with the occurrence of isoniazid-induced peripheral neuritis. Subsequent steps by various investigators were necessary to establish the genetic control of this individuality and the population differences in the proportion of fast and slow acetylators of that drug.…”

Section: Life Without Pharmcogeneticsmentioning

confidence: 99%

Pharmacogenetics: Its Place in Medicine and Biology

Kalow

1992

Journal of Pharmacy Practice

View full text Add to dashboard Cite

A young science serves its purpose if it leads not only to new knowledge, but to new insights and concepts. This article opens with examples to illustrate some former thinking that the introduction of pharmacogenetic has overcome. Pharmacogenetic case histories from discovery to the present illustrate the interlocking of observations, technical advances, and changing concepts. There are striking biological similarities between pharmacogenetics and those inborn factors that cause resistance to infectious disease: Both represent person-to-person variations that may help the survival of populations, one when facing massive toxic exposures, the other when facing plagues and epidemics. Thus pharmacogenetics represents a biologically necessary variability of the defenses against chemical intruders, and this includes drugs. While this variability is desirable, drug toxicity occurring on the basis of this variability must be avoided. The most successful defendants against toxicity due to polymorphic (ie, high incidence) variants should be the designers of new drugs. The only defender concerned with rare variants can be the attentive clinician.

show abstract

“…For instance, metropolol tends to cause bradycardia when the cytochrome CYP2D6 is missing, 49 or there is a relationship between warfarin-induced bleeding events and CYP2C9 activity, 50 or isoniacid causes unpleasant effects when Nacetyltransferase activity is lacking. 51 Thus, some cases of clinical usefulness of pharmaco-genetics and -genomics are well established.…”

Section: Personalized Medicinementioning

confidence: 99%