Enzymdiagnostik im Menschlichen Parotisspeichel und Ihre Probleme

Skurk, A; Fendel, K; Albrecht, R.

doi:10.3109/00016487609119968

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Grundlegende Arbeiten zum Sekretionsverhalten des glandulären Kallikreins der Ohrspeicheldrüse wurden bereits in den 70er Jahren vorgelegt [6,22,23]. Obwohl bis heute eine spezifische physiologische Funktion des Speichelkallikreins nicht gesichert ist [11], sind, wenn auch wenige klinisch interessante Arbeiten über Speichelkallikreine vorgelegt worden.…”

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Quantitative Untersuchungen am Kallikrein-Prokallikrein-System im Mischspeichel beim oralen Plattenepithelkarzinom

Meyer

Werner

Bankau

1997

HNO

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Few biochemical analyses on the mixed salivary kallikrein-prokallikrein system exist. At present, there is no statistically relevant information about possible relationships between mixed salivary kallikreins and malignant processes, especially oral squamous cell carcinoma. In order to prove quantitative alterations of the kallikrein-prokallikrein system in the presence of oral squamous cell carcinoma, we estimated the enzyme content in mixed saliva from 15 men with oral squamous cell carcinoma and proenzyme in 14 men with the same tumors. Seventeen males served as controls for enzyme and 16 for proenzyme. Enzymatic cleavage of the chromogenetic tripeptide DL-Val-Leu-Arg-p-nitranilide was used. Additionally, we investigated a control group of 17 women of the same age as the males in order to record normal enzyme and proenzyme levels. The Mann-Whitney-Wilcoxon test showed highly significant elevation of mixed saliva kallikrein (P = 0.0003) and a highly significant increase in prokallikrein (P = 0.0012) in patients with the oral squamous cell carcinomas. The present findings indicate a probable biochemical role of the mixed saliva kallikrein and prokallikrein in the pathogenesis of oral tumors.

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Quantitative Untersuchungen am Kallikrein-Prokallikrein-System im Mischspeichel beim oralen Plattenepithelkarzinom

Meyer

Werner

Bankau

1997

HNO

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16 Speekselklieraandoeningen en speeksel

Amerongen

2008

Speeksel, Speekselklieren en Mondgezondheid

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Influence of sex and age on kallikrein excretion in stimulated human parotid saliva

Maier¹,

Menstell²

1986

Arch Otorhinolaryngol

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We determined the activity of parotid salivary kallikrein in 65 healthy males and females. We then formed two groups of probands by age. The mean age in the first group (n = 35) was 24.5 +/- 1.7 years, whereas the mean age in the second group (n = 30) was 58.1 +/- 10.5 years. The activity of the glandular kallikrein was measured with a chromogenic substrate. The salivary kallikrein excretion in the younger females was higher when compared with that in the younger males. No sex differences concerning salivary kallikrein activity could be observed in the second group. A possible influence of female sex hormone on salivary kallikrein excretion is discussed.

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Enzymdiagnostik im Menschlichen Parotisspeichel und Ihre Probleme

Cited by 4 publications

References 6 publications

Quantitative Untersuchungen am Kallikrein-Prokallikrein-System im Mischspeichel beim oralen Plattenepithelkarzinom

Quantitative Untersuchungen am Kallikrein-Prokallikrein-System im Mischspeichel beim oralen Plattenepithelkarzinom

16 Speekselklieraandoeningen en speeksel

Influence of sex and age on kallikrein excretion in stimulated human parotid saliva

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