Enzyme-activated prodrugs and their release mechanisms for the treatment of cancer

Abstract

Enzyme-activated prodrugs have received a lot of attention in recent years. These prodrugs have low toxicity to cells before they are activated, and when they interact with specific enzymes, they...

4D printing for biomedical applications

“…221,222 This strategy has garnered substantial attention, especially in the domain of cancer therapies, and exhibits considerable promise for clinical translation. 223,224 4.3 Biomimicry and dynamic in vitro systems Mature tissues and organs attain their intricate forms via structural remodeling, reorganization, and morphogenesis through developmental processes. Nevertheless, conventional 3D bioprinting techniques yield static constructs that lack the ability to replicate the dynamic nature of native tissues.…”

“…221,222 This strategy has garnered substantial attention, especially in the domain of cancer therapies, and exhibits considerable promise for clinical translation. 223,224…”

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

“…11,12 In recent years, photodynamic therapy has gradually entered the clinical treatment of bacterial infections due to its advantages of low dark toxicity, high selectivity and low risk of bacterial resistance. [13][14][15][16] However, for wound infections caused by Gram-negative bacteria, some small-molecule photosensitizers are unable to impart the expected effect due to the inability to counteract the outer membrane barrier. Fortunately, antimicrobial peptides (AMPs), which have a destructive effect on the bacterial surface, impart a synergistic antimicrobial effect with photosensitizers.…”