Enzyme-alterable alkylating agents. I. Synthesis, chemical properties, and toxicities of sulfur mustards containing enzyme-susceptible amide bonds

Enzyme-alterable alkylating agents. II. Clinical evaluation of N, N′-bis[(2-chloroethylthio)acetyl]-1,2-ethylenediamine (S-46)

“…T h e compound selected was N,N'-bis-[(2-( hloi oe thy1 thio)acetyl]-1 ,2-ethylonediamine (S-46). Products of enzymatic cleavage of S-46 are ielatively nontoxic, Ttie synthesis of S-46 and its chetnical, billchemical, and toxicological properties have been reported in the first paper of this serics.5 11 is n highly vesicant, crystalline solid (with a melting point of 90 to 90.5' C.), stable for h o i i t 5 in diniethylacetamide but ixristable in nqueoiis solution. Accordingly, fresh solutions niwt be prepared immediately prior to its xltiiinistration.…”

Bronchial artery perfusion for treatment of advanced lung cancer

“…7.35 Another simple method of treatment is continuous intraaortic infusion, using a small catheter with the tip at the level of the fifth thoracic vertebra at or above the level of origin of the bronchial arteries.ll Perfusion of the entire upper body (hemibody perfusion) with protection of the remainder of the body was designed in the expectation that this would permit an increase in dosage to the lungs. An aortic balloon to occlude the aorta at the diaphragm failed to work because of the efficient collateral circulation around this site.21 A method of mid-torso occlusion using an aortic balloon and a large pneumatic tourniquet or an esmarch bandage wrapped' tightly around patient, table, and sandbags was then designed.9~ 33, 44 Others have eliminated the balloon catheter in the aorta, believing that adequate occlusion can be obtained by properly placed sandbags under tlie tourniquet.Zi9 33. 44 Miller et al infused methotrexate into the superior vena cava or atrium while citrovorum factor was infused into tlie aorta.2j It was reported that palliation was obtained in all 6 patients with lung cancer treated in this way.25…”