Enzyme assays in liver disease.

Wieme, R.J.; Demeulenaere, L

doi:10.1136/jcp.s1-4.1.51

Cited by 18 publications

(13 citation statements)

References 49 publications

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“…Serum AST and ALP activities have long been considered as the sensitive indicators for liver dysfunction [38,39]. When the liver is in dysfunction, alteration of the permeability of liver cell membranes leads to leakage of these enzymes from the cells [40]. As a result, cytoplasmic enzymes such as AST and ALP are released into the serum, the levels of the above enzymes will rise [39].…”

Section: Discussionmentioning

confidence: 99%

Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats

Smee

Ding

et al. 2009

Journal of Inorganic Biochemistry

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Section: Discussionmentioning

confidence: 99%

Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats

Smee

Ding

et al. 2009

Journal of Inorganic Biochemistry

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“…eases of the liver, the biliary tract and the pancreas [21]; in bone disease a rise in the activity of ALP does not parallel an increase in 5'-nucleotidase and y-GT [22], It has been shown that vitamin D metabo lites also increase the cytosol fraction of ALP [8]. It is well established that there is a sea sonal change in the blood levels of 2 5-hy droxy vitamin D (25-OHD) in normal and diseased subjects [5,18].…”

Section: Introductionmentioning

confidence: 99%

Seasonal Changes in the Activity of Serum Alkaline Phosphatase

Ms¹,

Cr²,

Bt³

1981

Enzyme

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This paper reports a seasonal variation in alkaline phosphatase (ALP) levels in the serum, with low values occurring in summer and high in winter. These variations were found both in indoor and outdoor workers and in a group of elderly women in a long-stay ward. The seasonal change in ALP was in the opposite direction to the seasonal change in the serum levels of 25-hydroxyvitamin D. No such change was seen in the serum levels of gamma- glutamyltransferase. It is suggested that the seasonal change in plasma ALP could be due to changes in the bone isoenzyme. Serum levels of calcium remained unchanged; the change in ALP may reflect a homeostatic mechanism controlling plasma calcium, which compensates for seasonal variations in vitamin D supply.

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“…Ordnung nach Wieme (8) ihren festen Platz in der Isoenzymanalytik haben, sind andere Methoden zur quantitativen Bestimmung der einzelnen Isoenzymfraktionen notwendig. Insbesondere den Methoden, die einer Mechanisierung zugänglich sind, wird bei einer größeren Probenfrequenz Bedeutung ziucommen.…”

Section: Diskussionunclassified

Aktivitätsbestimmung des placentalen Isoenzyms der alkalischen Phosphatase im Serum: Ein Methodenvergleich

Bayer¹,

Gabl²,

Knoth³

1979

Clinical Chemistry and Laboratory Medicine

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Zusammenfassung: Es wurden drei Methoden zur Bestimmung der Aktivität des placentalen Isoenzyms der alkalischen Phosphatase (EC 3.1.3.1) im menschlichen Serum verglichen:1. Hitzeinaktivierung bei 65 °C durch 10 Minuten, 2. Differentialinaktivierung mit ,-p-Bromtetramisol und 3. ein immunologischer Präzipitationstest.Die Ergebnisse der drei Methoden korrelieren gut (Korrelationskoeffizienten zwischen 0,973 und 0,982). Für größere Serien oder zur Screeninguntersuchung auf das Vorkommen von ,JRegan-hoenzym" eignet sich die Methode der Differentialinaktivierung mit ,-p-Bromtetramisol wegen der kurzen Analysenzeit und der relativ einfachen Mechanisierbarkeit am besten. Measuring the activity of the placental isoenzyme of alkaline phosphatase: 3 methods comparedSummary: Three methods were compared in human serum for determining the activity of the placental isoenzyme of alkaline phosphatase: . 1.Heat inactivation at 65 °C for 10 minutes, 2. Differential inactivation with L-p-Brpmotetramisole, and 3. an immunological precipation test.

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Enzyme assays in liver disease.

Cited by 18 publications

References 49 publications

Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats

Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats

Seasonal Changes in the Activity of Serum Alkaline Phosphatase

Aktivitätsbestimmung des placentalen Isoenzyms der alkalischen Phosphatase im Serum: Ein Methodenvergleich

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