Enzyme assays in the management of pregnancy.

Curzen, Peter

doi:10.1136/jcp.s1-4.1.90

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…In present study it was observed that serum alkaline phosphatase levels were significantly high in preeclamptic cases as compared to normotensive controls. This finding is in accordance to previous workers like Curzen P [26], Mangal et al [8] and Kapoor et al [27] Women with high maternal blood pressure had higher levels of serum alkaline phosphatase and increased intensity of PALP localization in placentae. Similar findings were reported by Mangal et al [8] and Curzen P. [14] Abnormally high serum alkaline phosphatase levels represent placental damage and failing placental function.…”

Section: Discussionsupporting

confidence: 83%

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Histochemistry of placental alkaline phosphatase in preeclampsia

Shevade

Arole

Paranjape

et al. 2016

Int J of Biomed & Adv Res

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Objectives: Placental alkaline phosphatase (PALP) is synthesized in placenta and increases with gestational age. Alkaline phosphatase supports pregnancy and could play an essential role in nutrient supply and growth of the fetus. Preeclampsia is a systemic disorder which affects 5 to 7 percent of women worldwide and is a major cause for maternal and neonatal morbidity and mortality. As it has a major role in fetal growth, nutrition and defense mechanism study of alkaline phosphatase enzymatic activity becomes essential. Methods: 50 normal and 50 preeclamptic placentae were collected immediately after delivery from Department of Obstetrics and Gynecology. Placentae were obtained from known preeclamptic consenting cases who had no history of hypertension before pregnancy or during first 20 weeks of gestation, who had consistently recorded systolic and diastolic blood pressure of 140 / 90 mm of Hg or above and proteinuria ≥ 300mg / 24 hrs. Alkaline phosphatase activity was demonstrated by using modified Gomori's method. Results: Intensity of PALP localization was stronger in preeclamptic placentae as compared to normotensive placentae. Conclusion: Placental ischemia is evident in preeclampsia. Uteroplacental insufficiency leads to increased syncytial damage in preeclamptic placentae which may lead to abnormally high PALP activity and consequent increase in serum alkaline phosphatase.

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Section: Discussionsupporting

confidence: 83%

“…This confirms placental origin of alkaline phosphatase in maternal serum. [8,26] IJBAR (2016) 07 (07) www.ssjournals.com…”

Section: Discussionmentioning

confidence: 99%

Histochemistry of placental alkaline phosphatase in preeclampsia

Shevade

Arole

Paranjape

et al. 2016

Int J of Biomed & Adv Res

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1 Clinical Enzymology

Goldberg¹

1976

Progress in Medicinal Chemistry

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Determination of Urinary and Serum β-Glucuronidase and Alkaline Phosphatase in Various Renal Disease and Kidney Rejection Transplanted Patients

Refaie

Abo-Zaid²,

Gomma³

et al. 2000

Preparative Biochemistry and Biotechnology

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Beta-glucuronidase (beta-Glu) and alkaline phosphatase (ALP) were evaluated in serum and urine in 50 subjects classified into five equal groups. Group I was control healthy subjects, while groups II, III, IV, and V were patients with nephritic syndrome, pyelonephritis, kidney rejection, and end-stage renal disease, respectively. Urinary beta-Glu was significantly elevated in all four groups; while serum enzyme showed no change. On the other hand, serum ALP showed a significant elevation in all abnormal groups. Accordingly, urinary beta-Glu and serum ALP could be used as diagnostic markers for various renal diseases.

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Enzyme assays in the management of pregnancy.

Cited by 5 publications

References 30 publications

Histochemistry of placental alkaline phosphatase in preeclampsia

Histochemistry of placental alkaline phosphatase in preeclampsia

1 Clinical Enzymology

Determination of Urinary and Serum β-Glucuronidase and Alkaline Phosphatase in Various Renal Disease and Kidney Rejection Transplanted Patients

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