Enzyme-based sensing on nanohybrid film coated over FTO electrode for highly sensitive detection of antibiotics

Chauhan, Nidhi; Balayan, Sapna; Gupta, Shruti; Singh, Jaskaran; Jain, Utkarsh

doi:10.1007/s00449-021-02618-3

Cited by 13 publications

(1 citation statement)

References 40 publications

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“…42 Sensors reported for quantitative determination of MER were few includes nanosensor using green Cu nanoparticles for its simultaneous determination with daptomycin in drinking water, 43 modified electrode GC/Gr/CNT-HQ/Fe-Ni along with linezolid in biological fluids, 44 and another sensor fabricated using platinum nanoparticles (PtNPs) and electrodeposited zinc oxide-zinc hexacyanoferrate hybrid film (ZnO/ZnHCF) on the surface of a fluorine-doped tin oxide electrode (FTO) for determination of cefepime and MER in different biological fluids. 45 Highly ordered pyrolytic graphite (HOPG) is highly pure graphite arranged from thermoplastic graphite, it acquired its importance in electrochemistry due to its versatile applicability to determine many compounds such as vitamins, 46 organophosphorus compounds in water and food samples by modifying PG with carbon nanotubes and silver nanoparticles 47 and some drugs prescribed for treatment of epilepsy with chronic inflammation. 48 Basal plane pyrolytic graphite electrode (BPPG) had been used as electrode material and as support for the development of modified electrodes, with good performance and some advantages.…”

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confidence: 99%

Electrochemical Sensor for Meropenem Therapeutic Monitoring in Human Plasma Based on Carbon Nanotubes Modified Basal Pyrolytic Graphite Electrode

Hegazy

Ghoniem

Yehia

et al. 2022

J. Electrochem. Soc.

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A sensitive, precise, and fast differential pulse voltammetric method has been developed for determination of meropenem (MER) in pure form, pharmaceutical dosage form, and human plasma. The fabricated sensors are based on basal-plane pyrolytic graphite electrode substrates that was modified by coating the surface with carbon nanotubes. The modified electrode showed detectable enhancement of the anodic peak current of meropenem from 25.8 to 35.7 µA. The effect of both pH and scan rate on peak current and potential were studied, and the optimum conditions were found to be at pH = 3.0 and scan rate of 100 mV.s-1. A linear response was obtained over the concentration range of 3.0×10-7 to 7.0×10-5 M MER in an aqueous buffer solution. The suggested sensor is highly sensitive, has a short response time, and is capable of MER detection as low concentration as 1.5×10-6 M in human plasma. The proposed sensor shows a great potential towards future fabrication of a point-of-care device to monitor MER level in patients’ plasma to ensure drug safety and efficacy for patients in intensive care unit.

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