2020
DOI: 10.1002/adfm.202006998
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Enzyme‐Degradable 3D Multi‐Material Microstructures

Abstract: There exists a growing need for smart materials suitable for use in biomedical applications. Herein, a photoresist that can be used to fabricate a biocompatible material entirely degradable by the enzyme chymotrypsin is introduced. The photoresist is based on a crosslinker with a tyramine moiety that is recognized and cleaved by the enzyme chymotrypsin. Macroscopic films as well as microstructures are fabricated via the use of direct laser writing. Multi-material boxing ring microstructures are generated and s… Show more

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Cited by 15 publications
(15 citation statements)
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“…The cell morphology stain by immunofluorescence and microscope imaging were performed as described previously [18]. Briefly, at 3 d, 7 d and 14 d timepoints, cell culture medium was removed and the mesh samples were transferred into a fresh 48-well plate.…”
Section: Cell Morphology: Fluorescent Microscopy and Semmentioning
confidence: 99%
“…The cell morphology stain by immunofluorescence and microscope imaging were performed as described previously [18]. Briefly, at 3 d, 7 d and 14 d timepoints, cell culture medium was removed and the mesh samples were transferred into a fresh 48-well plate.…”
Section: Cell Morphology: Fluorescent Microscopy and Semmentioning
confidence: 99%
“…The resin chemistries used currently in PμSL based degradable 3D printed parts include poly(propylene fumarates) and copolymers thereof, biobased polyesters, and thiol‐yne chemistry. [ 15,29–32 ] Although promising, these resin chemistries have limited tunability over degradation rate and behavior. Moreover, the synthesis of these multifunctional macromers that form degradable networks commonly involves multiple functionalization and purification steps, which makes the development of large numbers of polymers with diverse properties difficult.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, multimaterial microstructures fabricated by DLW were selectively dissolved by the digestive enzyme chymotrypsin. [ 98 ] Although these examples of biodegradable polymeric microrobots were actuated using magnetic forces, the concepts can be directly translated to light‐controlled microrobots.…”
Section: Light‐based Ingredientsmentioning
confidence: 99%