Enzyme-digestible swelling hydrogels as platforms for long-term oral drug delivery: synthesis and characterization

Park, K.

doi:10.1016/0142-9612(88)90009-9

Cited by 89 publications

(45 citation statements)

References 19 publications

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“…1993). The size-related retention of a dosage form in the stomach has been studied with various systems to include systems such as swelling balloon hydrogels (Park and Park, 1987) or unfolding stratified medicated polymer sheets (BE Patent No. 867,692) or non-erodible or erodible tetrahedron shaped devices (Cargill et ai., 1988(Cargill et ai., , 1989.…”

Section: Absorption Enhancement In Oral Drug Delivery Systemsmentioning

confidence: 99%

Biopolymer Mucoadhesives

Harding

Davis

Deacon

et al. 1999

Biotechnology and Genetic Engineering Reviews

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Section: Absorption Enhancement In Oral Drug Delivery Systemsmentioning

confidence: 99%

Biopolymer Mucoadhesives

Harding

Davis

Deacon

et al. 1999

Biotechnology and Genetic Engineering Reviews

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“…Park and Park reported medicated polymeric sheets and swelling of balloon hydrogels. 7 But the swelling and expanding systems may show hazard of permanent retention. Bioadhesive systems may cause problems such as irritation of the mucous layer owing to high localized concentration of the drug.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of diltiazem hydrochloride-gelucire 43/01 floating granules prepared by melt granulation

et al. 2004

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The basic objective of this study was to explore the application of Gelucire 43/01 for the design of multi-unit floating systems of a highly water-soluble drug diltiazem HCl. Diltiazem HCl-Gelucire 43/01 granules were prepared by melt granulation technique. The granules were evaluated for in vitro and in vivo floating ability, surface topography, and in vitro drug release. Aging effect on storage was evaluated using scanning electron microscopy, hot stage polarizing microscopy (HSPM), differential scanning calorimetry (DSC), and in vitro drug release. Granules were retained in stomach at least for 6 hours. Approximately 65% to 80% drug was released over 6 hours with initial fast release from the surface. Surface topography, HSPM, DSC study of the aged samples showed phase transformation of Gelucire. The phase transformation also caused significant increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01, can be considered as an effective carrier for design of a multi-unit floating drug delivery system of highly water-soluble drugs such as diltiazem HCl.

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“…Park and Park reported on medicated polymeric sheets and swelling of balloon hydrogels. 7 But with swelling and expanding systems there is a risk of permanent retention. Bioadhesive systems may cause problems such as irritation of the mucous layer owing to high localized concentration of the drug.…”

Section: Introductionmentioning

confidence: 99%

Floating granules of ranitidine hydrochloride-gelucire 43/01: Formulation optimization using factorial design

Patel

et al. 2007

AAPS PharmSciTech

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The purpose of this research was to develop and optimize a controlled-release multiunit floating system of a highly water soluble drug, ranitidine HCl, using Compritol, Gelucire 50/13, and Gelucire 43/01 as lipid carriers. Ranitidine HCllipid granules were prepared by the melt granulation technique and evaluated for in vitro floating and drug release. Ethyl cellulose, methylcellulose, and hydroxypropyl methylcellulose were evaluated as release rate modifiers. A 3 2 full factorial design was used for optimization by taking the amounts of Gelucire 43/01 (X 1 ) and ethyl cellulose (X 2 ) as independent variables, and the percentage drug released in 1(Q 1 ), 5(Q 5 ), and 10 (Q 10 ) hours as dependent variables. The results revealed that the moderate amount of Gelucire 43/01 and ethyl cellulose provides desired release of ranitidine hydrochloride from a floating system. Batch F4 was considered optimum since it contained less Gelucire and was more similar to the theoretically predicted dissolution profile (f 2 = 62.43). The temperature sensitivity studies for the prepared formulations at 40°C/75% relative humidity for 3 months showed no significant change in in vitro drug release pattern. These studies indicate that the hydrophobic lipid Gelucire 43/01 can be considered an effective carrier for design of a multiunit floating drug delivery system for highly water soluble drugs such as ranitidine HCl.

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Enzyme-digestible swelling hydrogels as platforms for long-term oral drug delivery: synthesis and characterization

Cited by 89 publications

References 19 publications

Biopolymer Mucoadhesives

Biopolymer Mucoadhesives

Preparation and evaluation of diltiazem hydrochloride-gelucire 43/01 floating granules prepared by melt granulation

Floating granules of ranitidine hydrochloride-gelucire 43/01: Formulation optimization using factorial design

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