Enzyme hybrid nanoflowers and enzyme@metal–organic frameworks composites: fascinating hybrid nanobiocatalysts

Immobilized cold-active enzymes onto magnetic chitosan microparticles as a highly stable and reusable carrier for p-xylene biodegradation

“…Nonetheless, conventional carriers used to obtain immobilized enzymes still face challenges, such as low immobilization efficiency, enzyme leakage, susceptibility to inactivation, and high resistance to mass transfer. These issues stem from limitations in carrier features, including a small specific surface area, irregular pore size distribution, poor biocompatibility, and a complex synthesis process (Li et al, 2023;Wang et al, 2023). An important challenge of using immobilized enzymes is the identification of new matrix materials with appropriate structural and morphological characteristics, as well as understanding enzyme-matrix interactions for improving catalysis (Kumari et al, 2018;Agrawal et al, 2020).…”

Stereoselective reduction of diarylmethanones via a ketoreductase@metal–organic framework

“…6–10 Largely owing to their well-defined pore structures and high surface areas, more recently, MOFs have also been employed for enzyme immobilization, with most studies focused on model enzymes such as cytochrome c, catalase, and glucose oxidase. 11–14 In contrast, application of MOF-derived biocomposites for (asymmetric) organic synthesis is still rare.…”

Advancements and Challenges in the Application of Metal-Organic Framework (MOF) Nanocomposites for Tumor Diagnosis and Treatment

“…Integrating biological materials has substantially enhanced our comprehension of crucial life processes, presenting an innovative platform to investigate complex biological phenomena and characterize their corresponding molecular pathways. [1][2][3][4][5] However, the complex intricacies of biomedicine pose a challenge for single-component organic and inorganic materials in terms of their biological functionality while ensuring biocompatibility, 6 as well as tackling concerns like cell or tissue toxicity. [7][8][9] To tackle this issue, scientists have deliberately dispersed nanoscale organic and inorganic components throughout a polymer matrix, granting the composite material unique physical, chemical, and biological characteristics.…”