Enzyme‐Immobilized Metal‐Organic Frameworks: From Preparation to Application

Abstract

As a class of widely used biocatalysts, enzymes possess advantages including high catalytic efficiency, strong specificity and mild reaction condition. However, most free enzymes have high requirements on the reaction environment and are easy to deactivate. Immobilization of enzymes on nanomaterial‐based substrates is a good way to solve this problem. Metal‐organic framework (MOFs), with ultra‐high specific surface area and adjustable porosity, can provide a large space to carry enzymes. And the tightly surrounded protective layer of MOFs can stabilize the enzyme structure to a great extent. In addition, the unique porous network structure enables selective mass transfer of substrates and facilitates catalytic processes. Therefore, these enzyme‐immobilized MOFs have been widely used in various research fields, such as molecule/biomolecule sensing and imaging, disease treatment, energy and environment protection. In this review, the preparation strategies and applications of enzyme‐immobilized MOFs are illustrated and the prospects and current challenges are discussed.

Direct Biocatalytic Processes for CO2 Capture as a Green Tool to Produce Value-Added Chemicals

“…Immobilization by entrapment occurs when a polymer, gel, or metal organic framework (MOF) is generated in the presence of an enzyme [ 132 , 166 ]. In such cases, the protein can remain trapped within the hollows of the polymer.…”

Application value and challenge of traditional Chinese medicine carried by ZIF‐8 in the therapy of ischemic stroke

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“…6–10 Largely owing to their well-defined pore structures and high surface areas, more recently, MOFs have also been employed for enzyme immobilization, with most studies focused on model enzymes such as cytochrome c, catalase, and glucose oxidase. 11–14 In contrast, application of MOF-derived biocomposites for (asymmetric) organic synthesis is still rare.…”