Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms

Paunel, Adnana N.; Dejam, André; Thelen, Sven; Kirsch, Michael; Horstjann, Markus; Gharini, Putrika Prastuti Ratna; Mürtz, Manfred; Kelm, Malte; Groot, Herbert de; Kolb-Bachofen, Victoria; Suschek, Christoph V.

doi:10.1016/j.freeradbiomed.2004.11.018

Cited by 108 publications

(100 citation statements)

References 34 publications

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“…The sun emits 20-fold more UVA than UVB; and, our relative exposure to UVA is further increased by wearing sunscreens, which allow us to remain outside longer without getting sunburned by UVB. In addition to photoaging, UVA contributes to UV-induced immune suppression [26][27][28], skin cancer formation [29,30], and ocular damage, such as cataracts [31,32]. Applying a high-absorbing UVA filter to window glass in a car, home, and office is an easy way to prevent passive exposure to UVA.…”

Section: Discussionmentioning

confidence: 99%

Measurement of protection afforded by ultraviolet-absorbing window film using an in vitro model of photodamage

Bernstein

Schwartz

Viehmeyer³

et al. 2006

Lasers Surg. Med.

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Window film that filters UV radiation results in dramatic reductions in cytotoxicity when measured by the neutral red uptake photoprotection assay. Widespread use of window film provides an ever-present barrier to ultraviolet A (UVA) exposure and could potentially reduce the detrimental effects of UVA, including photoaging, skin cancer, and ocular damage, such as cataracts. In addition, such film is essential for patients suffering from conditions sensitive to UV radiation, such as lupus erythematosis.

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Section: Discussionmentioning

confidence: 99%

Measurement of protection afforded by ultraviolet-absorbing window film using an in vitro model of photodamage

Bernstein

Schwartz

Viehmeyer³

et al. 2006

Lasers Surg. Med.

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“…40 ). In UVB-exposed keratinocytes an increased expression of iNOS and a large induction of NO were demonstrated.…”

Section: Nitric Oxide Synthasementioning

confidence: 99%

Ultraviolet Light Induced Alteration to the Skin

Svobodová¹,

Walterová²,

Vostalová³

2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

312

243

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“…It is unclear whether these nitroalkene PPARγ agonists are relevant to photobiology. However, UV irradiation is known to induce NO production through both enzymatic and non-enzymatic mechanisms 63,64 .…”

Section: Evidence That Oxidized Gpc Are Native Pparγ Ligandsmentioning

confidence: 99%

Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

Konger

Marathe

Yao

et al. 2008

Prostaglandins & Other Lipid Mediators

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Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.

show abstract

Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms

Cited by 108 publications

References 34 publications

Measurement of protection afforded by ultraviolet-absorbing window film using an in vitro model of photodamage

Measurement of protection afforded by ultraviolet-absorbing window film using an in vitro model of photodamage

Ultraviolet Light Induced Alteration to the Skin

Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

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