2023
DOI: 10.1021/cbmi.3c00117
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Enzyme-Instructed CBT-Cys-like Click Cyclization Reactions for Bioimaging

Yang Yang,
Xiaoyang Liu,
Xiaofeng Wu
et al.

Abstract: With high efficiency, mild conditions, and rapid reaction rate, click reactions have garnered much attention in the field of bioimaging since proposed by Sharpless et al. in 2001 (Angew. Chem., Int. Ed. 2001, 40, 2004. Inspired by the regenerative pathway of D-luciferin in fireflies, Liang et al. (Nat. Chem. 2010, 2, 54−60) raised a 2-cyanobenzothiazole (CBT)-cysteine (Cys) click condensation reaction in 2010, which exhibits a higher secondorder reaction rate (9.19 M −1 s −1 ) and superior biocompatibility. A… Show more

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Cited by 4 publications
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“…Second, enzyme-triggered biocompatible reaction that manipulates molecular self-assembly. With the introduction of various imaging moieties, E-MISA probes with different imaging modalities can be designed. , By introducing different therapeutic groups, it is feasible to construct therapeutic E-MISA probes for chemotherapy, phototherapy, sonodynamic therapy (SDT), and combination therapy. Furthermore, theranostic E-MISA probes can also be designed by integrating both imaging and therapeutic components.…”
Section: General Strategies For the Design Of E-misa Probesmentioning
confidence: 99%
“…Second, enzyme-triggered biocompatible reaction that manipulates molecular self-assembly. With the introduction of various imaging moieties, E-MISA probes with different imaging modalities can be designed. , By introducing different therapeutic groups, it is feasible to construct therapeutic E-MISA probes for chemotherapy, phototherapy, sonodynamic therapy (SDT), and combination therapy. Furthermore, theranostic E-MISA probes can also be designed by integrating both imaging and therapeutic components.…”
Section: General Strategies For the Design Of E-misa Probesmentioning
confidence: 99%