Encyclopedia of Drug Metabolism and Interactions 2012
DOI: 10.1002/9780470921920.edm003
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Enzyme Kinetics of Drug‐Metabolizing Reactions and Drug–Drug Interactions

Abstract: In vitro studies play an important role in characterizing biotransformation reactions. Kinetic parameters are determined during the early phases of drug discovery and development and provide invaluable information needed to predict in vivo metabolism and assess potential interactions with enzyme effectors. In order to obtain reliable and accurate in vitro data that reflect the in vivo situation, one must employ well‐defined enz… Show more

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“…The ratio between the resulting V max and K m values�often referred to as the in vitro intrinsic clearance�provides a relative analysis of the metabolization efficiencies. 37 With both curvefitting methods, AOH seems to be metabolized the slowest in pigs, followed by humans and rats. The phase I biotransformation efficacy order for AME is similar to that of AOH according to the Michaelis−Menten model.…”
Section: ■ Resultsmentioning
confidence: 99%
“…The ratio between the resulting V max and K m values�often referred to as the in vitro intrinsic clearance�provides a relative analysis of the metabolization efficiencies. 37 With both curvefitting methods, AOH seems to be metabolized the slowest in pigs, followed by humans and rats. The phase I biotransformation efficacy order for AME is similar to that of AOH according to the Michaelis−Menten model.…”
Section: ■ Resultsmentioning
confidence: 99%