Enzyme-Like Properties of Gold Clusters for Biomedical Application

Zhang, Yunguang; Li, Shuo; Liu, Haile; Long, Wei; Zhang, Xiaodong

doi:10.3389/fchem.2020.00219

Cited by 54 publications

(34 citation statements)

References 104 publications

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“…The unique enzyme-like activity of ultra-small Au NPs, the catalytic sites on their surface, and their good stability and biocompatibility give them potential as nanozymes in biomedicine. [235][236][237] For instance, dendritic polymer PAMAM-modified ultra-small Au NPs can autocatalyze the decomposition of hydrogen peroxide to oxygen in an acidic environment, achieve enhanced photodynamic therapeutic effects in combination with photosensitizers. 238 Atomically engineered ultra-small Au NPs can meet the expectation of having enzymelike activity while maintaining high stability, resulting in efficient antioxidant activity and catalytic activity.…”

Section: Nanozymementioning

confidence: 99%

High Stability Au NPs: From Design to Application in Nanomedicine

Zhang¹,

Shao²,

Yue³

et al. 2021

IJN

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In recent years, Au-based nanomaterials are widely used in nanomedicine and biosensors due to their excellent physical and chemical properties. However, these applications require Au NPs to have excellent stability in different environments, such as extreme pH, high temperature, high concentration ions, and various biomatrix. To meet the requirement of multiple applications, many synthetic substances and natural products are used to prepare highly stable Au NPs. Because of this, we aim at offering an update comprehensive summary of preparation high stability Au NPs. In addition, we discuss its application in nanomedicine. The contents of this review are based on a balanced combination of our studies and selected research studies done by worldwide academic groups. First, we address some critical methods for preparing highly stable Au NPs using polymers, including heterocyclic substances, polyethylene glycols, amines, and thiol, then pay attention to natural product progress Au NPs. Then, we sum up the stability of various Au NPs in different stored times, ions solution, pH, temperature, and biomatrix. Finally, the application of Au NPs in nanomedicine, such as drug delivery, bioimaging, photothermal therapy (PTT), clinical diagnosis, nanozyme, and radiotherapy (RT), was addressed concentratedly.

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Section: Nanozymementioning

confidence: 99%

High Stability Au NPs: From Design to Application in Nanomedicine

Zhang¹,

Shao²,

Yue³

et al. 2021

IJN

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“…The first system currently under investigation in our group is a Co 3+ ‐crosslinked polymer network based on kinetically inert metal‐ligand interactions which has redox responsiveness (Figure 5a). Gold clusters with GOx‐like activity [32a] can be embedded in the polymer network. Upon the addition of abiotic chemical fuels (e. g., ascorbic acid and glucose) to the damage site of the polymer networks, the local metal‐ligand interactions would become highly dynamic because of the high ligand exchange rate in the reduced Co 2+ ‐based systems.…”

Section: Systems Chemistry To Regulate the Healing Ability Of Materialsmentioning

confidence: 99%

Systems Chemistry in Self‐Healing Materials

Hao

2021

ChemSystemsChem

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Self‐healing materials are a kind of intelligent materials that have the ability to repair themselves after damage. By using chemical reaction networks to temporarily control the dynamics of covalent or coordination bonds, systems chemistry has recently shown great promise to reconcile the contradiction between the kinetic stability/inertness and intrinsic healing ability of synthetic materials. When compared to the traditional self‐healing strategies for synthetic materials, the regulation of the healing ability of materials by systems chemistry looks clumsy, but it represents a way similar to the self‐healing in biological systems, which is essentially regulated by complex biochemical reaction networks. Therefore, this field is worthy of further studies. In this Minireview, the significance, achievements and expectations of systems chemistry in regulating the healing ability of synthetic materials are discussed. We hope that it would be an inspiration for creating smart self‐healing materials with life‐like properties.

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“…After photoinduction and charge separation, each one of LUMO electrons and HOMO holes migrate to the NC surface and promote reduction or oxidation catalytic activity. [4,[32][33] Metal NCs are a new class of artificial enzyme, which presenting catalytic activity under mild conditions with better stability than natural enzymes. All detection methods (diagnosis) and generation mechanisms of the intrinsic reactive oxygen species (ROS generation) are based on these reactions.…”

Section: Nonradiative Decaymentioning

confidence: 99%

Bridging from Metallic Nanoclusters to Biomedical in Understanding Physicochemical Interactions at the Nano–Bio Interface

Borghei

Hosseinkhani

Ganjali

2021

Part & Part Syst Charact

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many important applications. When the metal NPs size (usually 10-100 nm) is further reduced to the size comparably to the Fermi wavelength of the electron, exhibit the electronic and optical properties which can distinguish them from NPs. [1][2][3] Small NCs have no plasmonic properties (not characteristic SPR absorption peak) and due to their small size exhibit quantum confinement effects (discrete electronic energy levels, not the energy bands found in nanoparticles) and are not conductors any more. Therefore, when the NCs interact with light, they possess some electronic properties through HOMO-LUMO (highest occupied and lowest unoccupied molecular orbital) electronic transitions. [4][5][6] In this review, the properties on the basis of photoexcitation energy are divided into two categories: when the photoexcitation energy is equal to or more than the bandgap (photon energy ≥ bandgap energy) and when the photoexcitation energy is far above the ionization energies of atoms such as X-and γ-rays (photon energy ≥ bandgap energy). About the first category, it was found that the relaxation from the excited state proceeds mainly from a nonradiative (via electron injection and energy transfer) [4] or radiative (luminescence) energy transfer. [7] And the relaxation in the second category is based on secondary products generation (Figure 1).For clarity and illustrating simplicity, the biomedical applications discussed in this review are categorized based on their physicochemical properties and all of them are schematically summarized (as shown in Figure 1). For example, when discussing the enzymatic activity of NCs, it is suggested that based on this feature, these types of nanostructures are used in biomedical applications such as photodynamic therapy, infection therapy, biosensing, etc. Photon Energy ≥ Bandgap Energy Radiative DecayLuminescence: The luminescence of NCs is caused by intraband and interband electronic transitions of metal core or due to the ligand-to-metal charge transfer (LMCT) and ligand-to-metalmetal charge transfer (LMMCT) (Figure 1 1)). It is not yet well defined whether this luminescence is fluorescence (i.e., from The current review is a guideline for a physicist/chemist/biologist/physician in the introduction of metallic nanocluster (NC) applications and selection of a suitable one from a medical perspective. Metallic nanoclusters have gained attention during recent years owing to their advantages of superior optical characteristics, long lifetime, and biocompatibility for nanomedicine applications, including biolabeling, biosensing, catalysis, bioimaging, drug/ gene delivery, and therapeutic agent in comparison to the semiconductor quantum dot analogs. Here their basic physicochemical properties are being introduced, and they are linked to biomedical opportunities. Introducing the needed concepts of noble metal-based nanomaterials is being tried here, along with giving a correct comprehension of the reason for its use in a particular part of biomedical over the last 20 years. Moreover, in each ...

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Enzyme-Like Properties of Gold Clusters for Biomedical Application

Cited by 54 publications

References 104 publications

High Stability Au NPs: From Design to Application in Nanomedicine

High Stability Au NPs: From Design to Application in Nanomedicine

Systems Chemistry in Self‐Healing Materials

Bridging from Metallic Nanoclusters to Biomedical in Understanding Physicochemical Interactions at the Nano–Bio Interface

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