Enzyme-linked immunosorbent assays for detecting antibody to Rickettsia australis in sera of various animal species

Huang, Zhibin; Graves, Stephen; Stewart, Linde; Banks, Joan; Dwyer, Brian

doi:10.1016/0147-9571(90)90274-w

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…Previous attempts to identify both the arthropod and vertebrate reservoirs of R. honei on Flinders Island were unsuccessful. 3,9 The current study identifies Ap. hydrosauri as an arthropod reservoir of R. honei.…”

Section: Discussionmentioning

confidence: 98%

Aponomma Hydrosauri, the Reptile-Associated Tick Reservoir of Rickettsia Honei on Flinders Island, Australia

et al. 2003

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Rickettsia honei is the etiologic agent of Flinders Island (Australia) spotted fever. The tick Aponomma hydrosauri is associated with reptiles and is the arthropod reservoir for this rickettsia on Flinders Island. The rickettsia appears to be maintained in the tick via vertical transmission. Of 46 ticks examined, 29 (63%) were positive for spotted fever group rickettsiae by detection of the citrate synthase gene by a polymerase chain reaction (PCR). From the positive tick samples, seven were sequenced and found to be 100% homologous with R. honei. Of 17 reptiles examined, none had evidence of rickettsiae by PCR or culture of blood.

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Section: Discussionmentioning

confidence: 98%

Aponomma Hydrosauri, the Reptile-Associated Tick Reservoir of Rickettsia Honei on Flinders Island, Australia

et al. 2003

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“…Moreover, the vast difference in the presence of tender lymphadenopathy (28% versus 70%) could represent different illnesses or organisms in previous studies, or differences in examination practices amongst medical practitioners. Thrombocytopenia, lymphopenia, and raised serum transaminases all occur in the majority of patients and are consistent in QTT [ 8 ]. Doxycycline is an uncommon cause of deranged liver function tests and can confound this marker of QTT infection during hospitalization [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Old infection was defined as an acute, clinically consistent illness in the recent past receiving successful treatment in patients that had no repeat epidemiological exposures and had presented to hospital for what was deemed an unrelated condition. The indirect microimmunofluorescence assay (IFA) utilizing an SFG-specific Rickettsia rickettsii antigen was used in serological testing [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Manifestations and Outcomes of Rickettsia australis Infection: A 15-Year Retrospective Study of Hospitalized Patients

Stewart

Armstrong

Graves³

et al. 2017

TropicalMed

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Queensland tick typhus (QTT; Rickettsia australis) is an important cause of community-acquired acute febrile illness in eastern Australia. Cases of QTT were identified retrospectively from 2000 to 2015 at five sites in Northern Brisbane through a pathology database. Those included had a fourfold rise in spotted fever group (SFG)-specific serology, a single SFG-specific serology ≥ 256 or SFG-specific serology ≥ 128 with a clinically consistent illness. Cases were excluded on the basis of clinical unlikelihood of QTT infection. Thirty-six cases were included. Fever was found in 34/36 (94%) patients. Rash occurred in 83% of patients with maculopapular being the dominant morphology (70%). Thrombocytopenia, lymphopenia, and raised transaminases were common and occurred in 58%, 69%, and 89% of patients, respectively. Thirty-one of 36 (86%) patients received antibiotic therapy (usually doxycycline) and the time to correct antibiotic (from admission) ranged from 3 to 120 h (mean 45.5 h). Four of 36 (11%) required intensive care unit (ICU) admission for severe sepsis and end-organ support. There were no deaths. QTT has a wide range of clinical and laboratory features. Early and appropriate antimicrobial therapy is important and may prevent severe disease. Further prospective studies are required to identify factors associated with severe infection and sepsis.

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“…from hosts and ticks, increases the difficulty of accurately defining the distribution and transmission of R. australis. 29 Serologic studies have been the predominate method of investigation. Molecular techniques may better characterize our understanding of R. australis epidemiology.…”

Section: Epidemiology and Ecology Of Vectorsmentioning

confidence: 99%

Rickettsia australis and Queensland Tick Typhus: A Rickettsial Spotted Fever Group Infection in Australia

Stewart

Armstrong

Graves³

et al. 2017

The American Society of Tropical Medicine and Hygiene

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, the etiologic agent of Queensland tick typhus (QTT), is increasingly being recognized as a cause of community-acquired acute febrile illness in eastern Australia. Changing human population demographics, climate change, and increased understanding of expanding vector distribution indicate QTT is an emerging public health threat. This review summarizes the epidemiology, pathogenesis, clinical features, treatment principles, and future directions of this disease. Increased recognition of QTT will enable consideration of and prompt treatment of infection by clinicians in Australia.

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Enzyme-linked immunosorbent assays for detecting antibody to Rickettsia australis in sera of various animal species

Cited by 4 publications

References 11 publications

Aponomma Hydrosauri, the Reptile-Associated Tick Reservoir of Rickettsia Honei on Flinders Island, Australia

Aponomma Hydrosauri, the Reptile-Associated Tick Reservoir of Rickettsia Honei on Flinders Island, Australia

Clinical Manifestations and Outcomes of Rickettsia australis Infection: A 15-Year Retrospective Study of Hospitalized Patients

Rickettsia australis and Queensland Tick Typhus: A Rickettsial Spotted Fever Group Infection in Australia

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