Enzyme-Responsive Release of Encapsulated Proteins from Biodegradable Hollow Capsules

Itoh, Yuki; Matsusaki, Michiya; Kida, Toshiyuki; Akashi, Mitsuru

doi:10.1021/bm060289y

Cited by 197 publications

(145 citation statements)

References 29 publications

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“…Degradation release occurs when enzymes, such as proteases, carbohydrases and lipases, degrade proteins, polysaccharides or lipids comprising the shell. Itoh et al (2006) prepared biodegradable chitosan capsules encapsulating proteins and explored the enzymatic degradation of the capsules in the presence of chitosanase by scanning electron microscopy (SEM). In contact with a solvent, the shell material can dissolve completely, quickly releasing the core or start to expand, favoring release.…”

Section: Controlled Releasementioning

confidence: 99%

Encapsulation of cosmetic active ingredients for topical application – a review

Casanova

Santos

2015

Journal of Microencapsulation

204

115

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Abstract:Microencapsulation is finding increasing applications in cosmetics and personal care markets. This paper provides an overall discussion on encapsulation of cosmetically active ingredients and encapsulation techniques for cosmetic and personal care products for topical applications. Some of the challenges are identified and critical aspects and future perspectives are addressed. Many cosmetics and personal care products contain biologically active substances that require encapsulation for increased stability of the active materials. The topical and transdermal delivery of active cosmetic ingredients requires effective, controlled and safe means of reaching the target site within the skin. Preservation of the active ingredients is also essential during formulation, storage and application of the final cosmetic product.Microencapsulation offers an ideal and unique carrier system for cosmetic active ingredients, as it has the potential to respond to all these requirements. The encapsulated agent can be released by several mechanisms, such as mechanical action, heat, diffusion, pH, biodegradation and dissolution. The selection of the encapsulation technique and shell material depends on the final application of the product, considering physical and chemical stability, concentration, required particle size, release mechanism and manufacturing costs.

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Section: Controlled Releasementioning

confidence: 99%

Encapsulation of cosmetic active ingredients for topical application – a review

Casanova

Santos

2015

Journal of Microencapsulation

204

115

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“…One of the first bioinspired functions of artificial cell membrane to be investigated in self‐assembled systems was the ability to respond to internal stimuli such as the presence of biomolecules and enzymes,9, 10, 11, 12, 13, 14, 15 redox conditions,16, 17, 18 or ionic strength19 and pH20, 21, 22, 23 of the environment and external stimuli such as light24, 25 or temperature26, 27 to control the transport behaviors. Most of these “smart” systems developed were used to elicit cargo release by a single stimulus 28…”

Section: Introductionmentioning

confidence: 99%

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

et al. 2016

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Multifunctional and responsive hollow capsules are ideal candidates to establish highly sophisticated compartments mimicking cell membranes for controllable bio‐inspired functions. For this purpose pH and temperature dual‐responsive and photo‐cross‐linked hollow capsules, based on silica‐templated layer‐by‐layer approach by using poly(N‐isopropyl acrylamide)‐block‐polymethacrylate) and polyallylamine, have been prepared to use them for the subsequent and easily available post‐encapsulation process of protein‐like macromolecules at room temperature and pH 7.4 and their controllable release triggered by stimuli. The uptake and release properties of the hollow capsules for cargos are highly affected by changes in the external stimuli temperature (25, 37, or 45 °C) and internal stimuli pH of the phosphate‐containing buffer solution (5.5 or 7.4), by the degree of photo‐cross‐linking, and the size of cargo. The photo‐cross‐linked and dual stimuli‐responsive hollow capsules with different membrane permeability can be considered as attractive material for mimicking cell functions triggered by controllable uptake and release of different up to 11 nm sized biomolecules.

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“…The incentive for such a drive is mainly owing to the vast advantages that it provides such as improved efficacy, reduced side effects and enhanced patient well-being. One of the major component for the creation of a potent controlled drug-delivery system are polymers such as polysodium 4-styrene sulfonate, polyallylamine hydrochloride, 2 chitosan, dextran sulfate, 3 etc. With the inception of various synthesis techniques, polymers with unique properties have been produced, which have opened the frontiers for designing drug-delivery systems with different release mechanisms and applications.…”

Section: Introductionmentioning

confidence: 99%

Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules

Thomas¹,

Radhakrishnan²,

Gnanadhas³

et al. 2013

IJN

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A novel polyelectrolyte nanocapsule system composed of biopolymers, chitosan and heparin has been fabricated by the layer-by-layer technique on silica nanoparticles followed by dissolution of the silica core. The nanocapsules were of the size range 200 ± 20 nm and loaded with the positively charged anticancer drug doxorubicin with an efficiency of 89%. The loading of the drug into the capsule happens by virtue of the pH-responsive property of the capsule wall, which is determined by the pKa of the polyelectrolytes. As the pH is varied, about 64% of the drug is released in acidic pH while 77% is released in neutral pH. The biocompatibility, efficiency of drug loading, and enhanced bioavailability of the capsule system was confirmed by MTT assay and in vivo biodistribution studies.

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Enzyme-Responsive Release of Encapsulated Proteins from Biodegradable Hollow Capsules

Cited by 197 publications

References 29 publications

Encapsulation of cosmetic active ingredients for topical application – a review

Encapsulation of cosmetic active ingredients for topical application – a review

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules

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