2023
DOI: 10.1101/2023.05.02.539073
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Enzyme stability-activity trade-off : new insights from protein stability weaknesses and evolutionary conservation

Abstract: A general limitation of the use of enzymes in biotechnological processes under sometimes non-physiological conditions is the complex interplay between two key quantities, enzyme activity and stability, where the increase of one is often associated with the decrease of the other. A precise stability-activity trade-off is necessary for the enzymes to be fully functional, but its weight in different protein regions and its dependence on environmental conditions is not yet elucidated. To advance this issue, we use… Show more

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