Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells

Abstract

Enzyme-treated asparagus extract (ETAS) contains various phytochemicals. It has been reported that ETAS protected early cognitive impairment of SAMP8 mice and Aβ-induced reduction of PC12 cell viability. In addition, ETAS had several functions on healthy people. The purpose of the present study was to investigate the effects of ETAS on normal memory function of rats and neurite-outgrowth of PC12 cells. ETAS significantly accelerated learning acquisition in in vivo and neurite-outgrowth in in vitro study. In conclusion, ETAS affected on memory function in early stage in normal rats. The basis of this effect may induce neurite-outgrowth in neurons.

Anti‐Inflammatory Effect of ETAS®50 by Inhibiting Nuclear Factor‐κB p65 Nuclear Import in Ultraviolet‐B‐Irradiated Normal Human Dermal Fibroblasts

“…A recent study also showed that ETAS 50 supplementation reduced the feelings of dysphoria and fatigue, ameliorated the quality of sleep, and enhanced stress-load performance as well as increasing salivary secretory immunoglobulin A levels in healthy adults [ 16 ]. In addition to these anti-stress effects, ETAS 50 has antiaging potencies via its ability to ameliorate cognitive impairment in senescence-accelerated mice [ 17 ], to protect neuronal PC-12 cells from amyloid β peptide-induced oxidative stress and cytotoxicity [ 18 ], and to improve learning ability in young healthy rats [ 19 ].…”

ETAS®50 Attenuates Ultraviolet‐B‐Induced Interleukin‐6 Expression by Suppressing Akt Phosphorylation in Normal Human Dermal Fibroblasts

“…It is a unique eco-friendly functional food that attenuates sleep deprivation-induced stress responses, promotes good sleep, and increases salivary secretory immunoglobulin A levels in mice and humans [ 13 – 15 ]. In addition to its antistress effects, later studies demonstrated the beneficial effects of ETAS 50 on brain functions, including the ability to ameliorate cognitive impairment in senescence-accelerated mice [ 16 ], protect neuronal PC-12 cells from amyloid β -induced cytotoxicity [ 17 ], and improve learning ability in young healthy rats [ 18 ].…”